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2NN7	Structure of inhibitor binding to Carbonic Anhydrase I Descriptor: Carbonic anhydrase 1, DIMETHYL SULFOXIDE, ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE, ... Authors: Christianson, D.W, Jude, K.M. Deposit date: 2006-10-23 Release date: 2007-05-08 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II. J.Am.Chem.Soc., 129, 2007
2NNG	Structure of inhibitor binding to Carbonic Anhydrase II Descriptor: 4-(2-AMINOETHYL)BENZENESULFONAMIDE, Carbonic anhydrase 2, GLYCEROL, ... Authors: Christianson, D.W, Jude, K.M. Deposit date: 2006-10-24 Release date: 2007-05-08 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II. J.Am.Chem.Soc., 129, 2007
2NNS	Structure of inhibitor binding to Carbonic Anhydrase II Descriptor: CHLORIDE ION, Carbonic anhydrase 2, GLYCEROL, ... Authors: Christianson, D.W, Jude, K.M. Deposit date: 2006-10-24 Release date: 2007-05-08 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.03 Å) Cite: Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II. J.Am.Chem.Soc., 129, 2007
2NN1	Structure of inhibitor binding to Carbonic Anhydrase I Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACID, Carbonic anhydrase 1, ... Authors: Christianson, D.W, Jude, K.M. Deposit date: 2006-10-23 Release date: 2007-04-24 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II J.Am.Chem.Soc., 129, 2007
2NNO	Structure of inhibitor binding to Carbonic Anhydrase II Descriptor: 3-[4-(AMINOSULFONYL)PHENYL]PROPANOIC ACID, Carbonic anhydrase 2, GLYCEROL, ... Authors: Christianson, D.W, Jude, K.M. Deposit date: 2006-10-24 Release date: 2007-05-08 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.01 Å) Cite: Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II. J.Am.Chem.Soc., 129, 2007
8CA2	ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION Authors: Alexander, R.S, Christianson, D.W. Deposit date: 1991-07-09 Release date: 1992-07-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Engineering the hydrophobic pocket of carbonic anhydrase II. Biochemistry, 30, 1991
2NWO	Structural and kinetic effect of hydrophobic mutations in the active site of human carbonic anhydrase II Descriptor: Carbonic anhydrase 2, ZINC ION Authors: Fisher, S.Z, McKenna, R. Deposit date: 2006-11-16 Release date: 2007-04-24 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II. Biochemistry, 46, 2007
2O4Z	Crystal structure of the Carbonic Anhydrase II complexed with hydroxysulfamide inhibitor Descriptor: Carbonic anhydrase 2, MERCURY (II) ION, N-hydroxysulfamide, ... Authors: Temperini, C, Winum, J.Y, Montero, J.L, Scozzafava, a, Supuran, c.t. Deposit date: 2006-12-05 Release date: 2007-05-15 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Carbonic anhydrase inhibitors: The X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors. Bioorg.Med.Chem.Lett., 17, 2007
8CO3	Three dimensional structure of human carbonic anhydrase XII in complex with sulfonamide Descriptor: 5-(5-methyl-6-quinolin-5-yl-pyridin-3-yl)thiophene-2-sulfonamide, Carbonic anhydrase 12, ZINC ION Authors: Leitans, J, Dvinskis, E, Tars, K. Deposit date: 2023-02-26 Release date: 2023-12-13 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Atropo/Tropo Flexibility: A Tool for Design and Synthesis of Self-Adaptable Inhibitors of Carbonic Anhydrases and Their Antiproliferative Effect. J.Med.Chem., 66, 2023
8CO0	Three dimensional structure of human carbonic anhydrase IX in complex with sulfonamide Descriptor: 5-(5-methyl-6-quinolin-5-yl-pyridin-3-yl)thiophene-2-sulfonamide, Carbonic anhydrase 9, GLYCEROL, ... Authors: Leitans, J, Tars, K. Deposit date: 2023-02-25 Release date: 2023-12-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Atropo/Tropo Flexibility: A Tool for Design and Synthesis of Self-Adaptable Inhibitors of Carbonic Anhydrases and Their Antiproliferative Effect. J.Med.Chem., 66, 2023
2NXS	Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II Descriptor: SULFATE ION, ZINC ION, carbonic anhydrase 2 Authors: Fisher, S.Z, McKenna, R. Deposit date: 2006-11-19 Release date: 2007-04-24 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II. Biochemistry, 46, 2007
8CDX	Human carbonic anhydrase I complexed with 4-(3-ethylureido)benzenesulfonamide Descriptor: 1-ethyl-3-(4-sulfamoylphenyl)urea, Carbonic anhydrase 1, ZINC ION Authors: Angeli, A, Ferraroni, M. Deposit date: 2023-02-01 Release date: 2024-02-21 Method: X-RAY DIFFRACTION (1.335 Å) Cite: Human carbonic anhydrase I complexed with 4-(3-ethylureido)benzenesulfonamide To Be Published
8CDZ	human carbonic anhydrase I complexed with 4-(3-butylureido)benzenesulfonamide Descriptor: 1-butyl-3-(4-sulfamoylphenyl)urea, Carbonic anhydrase 1, DIMETHYL SULFOXIDE, ... Authors: Angeli, A, Ferraroni, M. Deposit date: 2023-02-01 Release date: 2024-02-21 Method: X-RAY DIFFRACTION (1.44 Å) Cite: human carbonic anhydrase I complexed with 4-(3-butylureido)benzenesulfonamide To Be Published
2NWY	Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase II Descriptor: ZINC ION, carbonic anhydrase 2 Authors: Fisher, S.Z, McKenna, R. Deposit date: 2006-11-16 Release date: 2007-04-24 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II. Biochemistry, 46, 2007
2NWZ	Structural and kinetic effects of hydrophobic mutations on the active site of human carbonic anhydrase II Descriptor: SULFATE ION, ZINC ION, carbonic anhydrase 2 Authors: Fisher, S.Z, McKenna, R. Deposit date: 2006-11-16 Release date: 2007-04-24 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II. Biochemistry, 46, 2007
2NXR	Structural effects of hydrophobic mutations on the active site of human carbonic anhydrase II Descriptor: SULFATE ION, ZINC ION, carbonic anhydrase 2 Authors: Fisher, S.Z, McKenna, R. Deposit date: 2006-11-19 Release date: 2007-04-24 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II. Biochemistry, 46, 2007
2NWP	Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II Descriptor: SULFATE ION, ZINC ION, carbonic anhydrase 2 Authors: Fisher, S.Z, McKenna, R. Deposit date: 2006-11-16 Release date: 2007-04-24 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II. Biochemistry, 46, 2007
2NXT	Structural and kinetic effects of hydrophobic mutations in the active site of human carbonic anhydrase II Descriptor: ZINC ION, carbonic anhydrase 2 Authors: Fisher, S.Z, McKenna, R. Deposit date: 2006-11-19 Release date: 2007-04-24 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.15 Å) Cite: Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II. Biochemistry, 46, 2007
8DJ9	Carbonic Anhydrase II in complex with Ibuprofen Descriptor: (2R)-2-[4-(2-methylpropyl)phenyl]propanoic acid, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Carbonic anhydrase 2, ... Authors: Combs, J.C, McKenna, R, Andring, J.T. Deposit date: 2022-06-30 Release date: 2022-11-09 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.54 Å) Cite: Ibuprofen: a weak inhibitor of carbonic anhydrase II. Acta Crystallogr.,Sect.F, 78, 2022
8DQF	Crystal structure of Neisseria gonorrhoeae carbonic anhydrase with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)cyclohexanecarboxamide Descriptor: Carbonic anhydrase, N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)cyclohexanecarboxamide, SULFATE ION, ... Authors: Marapaka, A.K, Das, C, Flaherty, D.P, Yadav, R. Deposit date: 2022-07-19 Release date: 2022-12-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural Characterization of Thiadiazolesulfonamide Inhibitors Bound to Neisseria gonorrhoeae alpha-Carbonic Anhydrase. Acs Med.Chem.Lett., 14, 2023
8DPC	Crystal structure of carbonic anhydrase from Neisseria gonorrhoeae Descriptor: Carbonic anhydrase, SULFATE ION, ZINC ION Authors: Marapaka, A.K, Das, C, Flaherty, D.P, Yadav, R. Deposit date: 2022-07-15 Release date: 2022-12-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Structural Characterization of Thiadiazolesulfonamide Inhibitors Bound to Neisseria gonorrhoeae alpha-Carbonic Anhydrase. Acs Med.Chem.Lett., 14, 2023
2OSF	Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study Descriptor: 4-MERCAPTOBENZENE-1,3-DIOL, Carbonic anhydrase 2, S-(2,4-dihydroxyphenyl) hydrogen thiocarbonate, ... Authors: Albert, A.B, Caroli, G, Govindasamy, L, Agbandje-McKenna, M, McKenna, R, Tripp, B.C. Deposit date: 2007-02-05 Release date: 2008-05-27 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study. Biochemistry, 47, 2008
8DPO	Crystal structure of Neisseria gonorrhoeae carbonic anhydrase with Acetazolamide Descriptor: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, Carbonic anhydrase, SULFATE ION, ... Authors: Marapaka, A.K, Das, C, Flaherty, D.P, Yadav, R. Deposit date: 2022-07-15 Release date: 2023-07-19 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structure of Neisseria gonorrhoeae carbonic anhydrase with Acetazolamide To Be Published
2OSM	Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study Descriptor: 2-MERCAPTOPHENOL, Carbonic anhydrase 2, ZINC ION Authors: Albert, A.B, Caroli, G, Govindasamy, L, Agbandje-Mckenna, M, McKenna, R, Tripp, B.C. Deposit date: 2007-02-06 Release date: 2008-02-12 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Inhibition of Carbonic Anhydrase II by Thioxolone: A Mechanistic and Structural Study. Biochemistry, 47, 2008
8DRB	Crystal structure of Neisseria gonorrhoeae carbonic anhydrase with 3-phenyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)propanamide Descriptor: 3-phenyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)propanamide, Carbonic anhydrase, SULFATE ION, ... Authors: Marapaka, A.K, Das, C, Flaherty, D.P, Yadav, R. Deposit date: 2022-07-20 Release date: 2022-12-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.59 Å) Cite: Structural Characterization of Thiadiazolesulfonamide Inhibitors Bound to Neisseria gonorrhoeae alpha-Carbonic Anhydrase. Acs Med.Chem.Lett., 14, 2023

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