2O4Z
Crystal structure of the Carbonic Anhydrase II complexed with hydroxysulfamide inhibitor
Summary for 2O4Z
Entry DOI | 10.2210/pdb2o4z/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (5 entities in total) |
Functional Keywords | carbonic anhydrase, inhibitors, lyase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29667.17 |
Authors | Temperini, C.,Winum, J.Y.,Montero, J.L.,Scozzafava, a.,Supuran, c.t. (deposition date: 2006-12-05, release date: 2007-05-15, Last modification date: 2023-08-30) |
Primary citation | Temperini, C.,Winum, J.Y.,Montero, J.L.,Scozzafava, A.,Supuran, C.T. Carbonic anhydrase inhibitors: The X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors. Bioorg.Med.Chem.Lett., 17:2795-2801, 2007 Cited by PubMed: 17346964DOI: 10.1016/j.bmcl.2007.02.068 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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