2NWO
Structural and kinetic effect of hydrophobic mutations in the active site of human carbonic anhydrase II
Summary for 2NWO
| Entry DOI | 10.2210/pdb2nwo/pdb |
| Related | 2NWP 2NWY 2NWZ 2NXR 2NXS 2NXT |
| Descriptor | Carbonic anhydrase 2, ZINC ION (3 entities in total) |
| Functional Keywords | proton transfer, histidine 64, carbonic anhydrase, lyase |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm : P00918 |
| Total number of polymer chains | 1 |
| Total formula weight | 29353.53 |
| Authors | Fisher, S.Z.,McKenna, R. (deposition date: 2006-11-16, release date: 2007-04-24, Last modification date: 2023-08-30) |
| Primary citation | Fisher, S.Z.,Tu, C.K.,Bhatt, D.,Govindasamy, L.,Agbandje-McKenna, M.,McKenna, R.,Silverman, D.N. Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II. Biochemistry, 46:3803-3813, 2007 Cited by PubMed: 17330962DOI: 10.1021/bi602620k PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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