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PDB: 42 results

3ZPQ
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Thermostabilised turkey beta1 adrenergic receptor with 4-(piperazin-1- yl)-1H-indole bound (compound 19)
Descriptor: 4-(PIPERAZIN-1-YL)-1H-INDOLE, BETA-1 ADRENERGIC RECEPTOR, CHOLESTEROL HEMISUCCINATE, ...
Authors:Christopher, J.A, Congreve, M, Dore, A.S, Marshall, F.H, Myszka, D.G, Brown, J, Koglin, M, Tehan, B, Errey, J.C, Tate, C.G, Warne, T.
Deposit date:2013-03-01
Release date:2013-04-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Biophysical Fragment Screening of the Beta1-Adrenergic Receptor: Identification of High Affinity Aryl Piperazine Leads Using Structure-Based Drug Design.
J.Med.Chem., 56, 2013
3ZPR
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Thermostabilised turkey beta1 adrenergic receptor with 4-methyl-2-(piperazin-1-yl) quinoline bound
Descriptor: 4-METHYL-2-(PIPERAZIN-1-YL) QUINOLINE, BETA-1 ADRENERGIC RECEPTOR, CHOLESTEROL HEMISUCCINATE, ...
Authors:Christopher, J.A, Congreve, M, Dore, A.S, Marshall, F.H, Myszka, D.G, Brown, J, Koglin, M, Tehan, B, Errey, J.C, Tate, C.G, Warne, T.
Deposit date:2013-03-01
Release date:2013-04-03
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Biophysical Fragment Screening of the Beta1-Adrenergic Receptor: Identification of High Affinity Aryl Piperazine Leads Using Structure-Based Drug Design.
J.Med.Chem., 56, 2013
8PM2
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BU of 8pm2 by Molmil
Structure of the murine trace amine-associated receptor TAAR7f bound to N,N-dimethylcyclohexylamine (DMCH) in complex with mini-Gs trimeric G protein
Descriptor: CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Gusach, A, Lee, Y, Edwards, P.C, Huang, F, Weyand, S.N, Tate, C.G.
Deposit date:2023-06-28
Release date:2023-08-09
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (2.92 Å)
Cite:Molecular recognition of an aversive odorant by the murine trace amine-associated receptor TAAR7f.
Biorxiv, 2023
6TKO
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Phosphorylated turkey beta1 adrenoceptor with bound agonist formoterol coupled to arrestin-2 in lipid nanodisc.
Descriptor: Beta-1 adrenergic receptor, Beta-arrestin-1, Fab30 heavy chain, ...
Authors:Lee, Y, Tate, C.G.
Deposit date:2019-11-28
Release date:2020-06-17
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Molecular basis of beta-arrestin coupling to formoterol-bound beta1-adrenoceptor.
Nature, 583, 2020
4UHR
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Thermostabilised HUMAN A2a Receptor with CGS21680 bound
Descriptor: 2-[P-(2-CARBOXYETHYL)PHENYLETHYL-AMINO]-5'-N-ETHYLCARBOXAMIDO ADENOSINE, THERMOSTABILISED HUMAN A2A RECEPTOR
Authors:Lebon, G, Edwards, P.C, Leslie, A.G.W, Tate, C.G.
Deposit date:2015-03-25
Release date:2015-04-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Determinants of Cgs21680 Binding to the Human Adenosine A2A Receptor.
Mol.Pharmacol., 87, 2015
4UG2
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Thermostabilised HUMAN A2a Receptor with CGS21680 bound
Descriptor: (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-[P-(2-CARBOXYETHYL)PHENYLETHYL-AMINO]-5'-N-ETHYLCARBOXAMIDO ADENOSINE, THERMOSTABILISED HUMAN A2A RECEPTOR
Authors:Lebon, G, Edwards, P.C, Leslie, A.G.W, Tate, C.G.
Deposit date:2015-03-21
Release date:2015-04-08
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Determinants of Cgs21680 Binding to the Human Adenosine A2A Receptor.
Mol.Pharmacol., 87, 2015
6FUF
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Crystal structure of the rhodopsin-mini-Go complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(o) subunit alpha, RETINAL, ...
Authors:Tsai, C.-J, Weinert, T, Muehle, J, Pamula, F, Nehme, R, Flock, T, Nogly, P, Edwards, P.C, Carpenter, B, Gruhl, T, Ma, P, Deupi, X, Standfuss, J, Tate, C.G, Schertler, G.F.X.
Deposit date:2018-02-27
Release date:2018-10-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.117 Å)
Cite:Crystal structure of rhodopsin in complex with a mini-Gosheds light on the principles of G protein selectivity.
Sci Adv, 4, 2018
6NIY
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A high-resolution cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex
Descriptor: Calcitonin, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:dal Maso, E, Glukhova, A, Zhu, Y, Garcia-Nafria, J, Tate, C.G, Atanasio, S, Reynolds, C.A, Ramirez-Aportela, E, Carazo, J.-M, Hick, C.A, Furness, S.G.B, Hay, D.L, Liang, Y.-L, Miller, L.J, Christopoulos, A, Wang, M.-W, Wootten, D, Sexton, P.M.
Deposit date:2019-01-02
Release date:2019-01-23
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (3.34 Å)
Cite:The Molecular Control of Calcitonin Receptor Signaling.
Acs Pharmacol Transl Sci, 2, 2019
6H7J
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ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST ISOPRENALINE AND NANOBODY Nb80
Descriptor: Beta-1 adrenergic receptor, Camelid antibody fragment Nb80, HEGA-10, ...
Authors:Warne, T, Edwards, P.C, Dore, A.S, Leslie, A.G.W, Tate, C.G.
Deposit date:2018-07-31
Release date:2018-10-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular basis for high-affinity agonist binding in GPCRs.
Science, 364, 2019
6H7L
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BU of 6h7l by Molmil
ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST DOBUTAMINE AND NANOBODY Nb6B9
Descriptor: Beta-1 adrenergic receptor, Camelid antibody fragment Nb6B9, DOBUTAMINE, ...
Authors:Warne, T, Edwards, P.C, Dore, A.S, Leslie, A.G.W, Tate, C.G.
Deposit date:2018-07-31
Release date:2018-10-17
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular basis for high-affinity agonist binding in GPCRs.
Science, 364, 2019
6H7O
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BU of 6h7o by Molmil
ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND WEAK PARTIAL AGONIST CYANOPINDOLOL AND NANOBODY Nb6B9
Descriptor: 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, Beta-1 adrenergic receptor, Camelid antibody fragment Nb6B9, ...
Authors:Warne, T, Edwards, P.C, Dore, A.S, Leslie, A.G.W, Tate, C.G.
Deposit date:2018-07-31
Release date:2018-10-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular basis for high-affinity agonist binding in GPCRs.
Science, 364, 2019
6H7N
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BU of 6h7n by Molmil
ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST XAMOTEROL AND NANOBODY Nb6B9
Descriptor: Beta-1 adrenergic receptor, Camelid antibody fragment Nb6B9, HEGA-10, ...
Authors:Warne, T, Edwards, P.C, Dore, A.S, Leslie, A.G.W, Tate, C.G.
Deposit date:2018-07-31
Release date:2018-10-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular basis for high affinity agonist binding in GPCRs
Biorxiv, 2018
6G79
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Coupling specificity of heterotrimeric Go to the serotonin 5-HT1B receptor
Descriptor: 2-[5-[2-[4-(4-cyanophenyl)piperazin-1-yl]-2-oxidanylidene-ethoxy]-1~{H}-indol-3-yl]ethylazanium, 5-hydroxytryptamine receptor 1B, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Garcia-Nafria, J, Nehme, R, Edwards, P, Tate, C.G.
Deposit date:2018-04-05
Release date:2018-06-20
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:Cryo-EM structure of the serotonin 5-HT1Breceptor coupled to heterotrimeric Go.
Nature, 558, 2018
6H7M
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BU of 6h7m by Molmil
ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND PARTIAL AGONIST SALBUTAMOL AND NANOBODY Nb6B9
Descriptor: Beta-1 adrenergic receptor, Camelid antibody fragment Nb6B9, HEGA-10, ...
Authors:Warne, T, Edwards, P.C, Dore, A.S, Leslie, A.G.W, Tate, C.G.
Deposit date:2018-07-31
Release date:2018-10-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Molecular basis for high-affinity agonist binding in GPCRs.
Science, 364, 2019
7QA8
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BU of 7qa8 by Molmil
Structure of the GPCR dimer Ste2 bound to an antagonist
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, HIS-ALA-LEU-GLN-LEU-LYS-PRO-GLY-GLN-PRO-NLE-TYR, ...
Authors:Velazhahan, V, Tate, C.G.
Deposit date:2021-11-16
Release date:2022-03-16
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Activation mechanism of the class D fungal GPCR dimer Ste2.
Nature, 603, 2022
7QBC
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BU of 7qbc by Molmil
Structure of the GPCR dimer Ste2 in the inactive-like state bound to agonist
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha factor pheromone, CHOLESTEROL HEMISUCCINATE, ...
Authors:Velazhahan, V, Tate, C.G.
Deposit date:2021-11-18
Release date:2022-03-16
Last modified:2022-04-06
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:Activation mechanism of the class D fungal GPCR dimer Ste2.
Nature, 603, 2022
7QB9
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Structure of the ligand-free GPCR dimer Ste2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Pheromone alpha factor receptor
Authors:Velazhahan, V, Tate, C.G.
Deposit date:2021-11-18
Release date:2022-03-16
Last modified:2022-04-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Activation mechanism of the class D fungal GPCR dimer Ste2.
Nature, 603, 2022
7QBI
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BU of 7qbi by Molmil
Structure of the GPCR dimer Ste2 in the active-like state bound to agonist
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha factor pheromone, CHOLESTEROL HEMISUCCINATE, ...
Authors:Velazhahan, V, Tate, C.G.
Deposit date:2021-11-19
Release date:2022-03-16
Last modified:2022-04-06
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Activation mechanism of the class D fungal GPCR dimer Ste2.
Nature, 603, 2022
6IBL
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BU of 6ibl by Molmil
ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST FORMOTEROL AND NANOBODY Nb80
Descriptor: Camelid antibody fragment Nb80, HEGA-10, SODIUM ION, ...
Authors:Warne, T, Edwards, P.C, Dore, A.S, Leslie, A.G.W, Tate, C.G.
Deposit date:2018-11-30
Release date:2019-01-09
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular basis of beta-arrestin coupling to formoterol-bound beta1-adrenoceptor.
Nature, 583, 2020
5G53
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Structure of the adenosine A2A receptor bound to an engineered G protein
Descriptor: ADENOSINE RECEPTOR A2A, ENGINEERED DOMAIN OF HUMAN G ALPHA S LONG ISOFORM, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Carpenter, B, Nehme, R, Warne, T, Leslie, A.G.W, Tate, C.G.
Deposit date:2016-05-19
Release date:2016-08-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of the Adenosine A2A Receptor Bound to an Engineered G Protein
Nature, 536, 2016
3PWH
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Thermostabilised Adenosine A2A Receptor
Descriptor: 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a
Authors:Dore, A.S, Robertson, N, Errey, J.C, Ng, I, Tehan, B, Hurrell, E, Magnani, F, Tate, C.G, Weir, M, Marshall, F.H.
Deposit date:2010-12-08
Release date:2011-09-07
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.296 Å)
Cite:Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine
Structure, 19, 2011
3RFM
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BU of 3rfm by Molmil
Thermostabilised adenosine A2A receptor in complex with caffeine
Descriptor: Adenosine receptor A2a, CAFFEINE
Authors:Dore, A.S, Robertson, N, Errey, J.C, Ng, I, Hollenstein, K, Tehan, B, Hurrell, E, Bennett, K, Congreve, M, Magnani, F, Tate, C.G, Weir, M, Marshall, F.H.
Deposit date:2011-04-06
Release date:2011-09-07
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.598 Å)
Cite:Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine
Structure, 19, 2011
3REY
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BU of 3rey by Molmil
Thermostabilised adenosine A2A receptor in complex with XAC
Descriptor: Adenosine receptor A2a, N-(2-aminoethyl)-2-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)phenoxy]acetamide
Authors:Dore, A.S, Robertson, N, Errey, J.C, Ng, I, Hollenstein, K, Tehan, B, Hurrell, E, Bennett, K, Congreve, M, Magnani, F, Tate, C.G, Weir, M, Marshall, F.H.
Deposit date:2011-04-05
Release date:2011-09-07
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.309 Å)
Cite:Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine
Structure, 19, 2011
4GRV
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The crystal structure of the neurotensin receptor NTS1 in complex with neurotensin (8-13)
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Neurotensin 8-13, Neurotensin receptor type 1, ...
Authors:Noinaj, N, White, J.F, Shibata, Y, Love, J, Kloss, B, Xu, F, Gvozdenovic-Jeremic, J, Shah, P, Shiloach, J, Tate, C.G, Grisshammer, R.
Deposit date:2012-08-27
Release date:2012-10-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.802 Å)
Cite:Structure of the agonist-bound neurotensin receptor.
Nature, 490, 2012
5A8E
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thermostabilised beta1-adrenoceptor with rationally designed inverse agonist 7-methylcyanopindolol bound
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, 4-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-7-methyl-1H-indole-2-carbonitrile, ...
Authors:Sato, T, Baker, J.G, Warne, T, Brown, G.A, Congreve, M, Leslie, A.G.W, Tate, C.G.
Deposit date:2015-07-15
Release date:2015-09-30
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Pharmacological Analysis and Structure Determination of 7-Methylcyanopindolol-Bound Beta1-Adrenergic Receptor.
Mol.Pharmacol., 88, 2015

 

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