3PWH

Thermostabilised Adenosine A2A Receptor

Summary for 3PWH

Entry DOI	10.2210/pdb3pwh/pdb
Descriptor	Adenosine receptor A2a, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol (2 entities in total)
Functional Keywords	7tm, gpcr, inverse agonist, g-protein, membrane protein, signaling protein
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Multi-pass membrane protein: P29274
Total number of polymer chains	1
Total formula weight	36816.44
Authors	Dore, A.S.,Robertson, N.,Errey, J.C.,Ng, I.,Tehan, B.,Hurrell, E.,Magnani, F.,Tate, C.G.,Weir, M.,Marshall, F.H. (deposition date: 2010-12-08, release date: 2011-09-07, Last modification date: 2023-11-01)
Primary citation	Dore, A.S.,Robertson, N.,Errey, J.C.,Ng, I.,Hollenstein, K.,Tehan, B.,Hurrell, E.,Bennett, K.,Congreve, M.,Magnani, F.,Tate, C.G.,Weir, M.,Marshall, F.H. Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine Structure, 19:1283-1293, 2011 Cited by PubMed: 21885291 DOI: 10.1016/j.str.2011.06.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.296 Å)

Structure validation