6G79

Coupling specificity of heterotrimeric Go to the serotonin 5-HT1B receptor

Summary for 6G79

• Entry DOI: 10.2210/pdb6g79/pdb
• EMDB information: 4358
• Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(o) subunit alpha, ... (5 entities in total)
• Functional Keywords: g-protein coupled receptor, 5-ht1b, mini-go, serotonin, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 111964.40

Authors

Garcia-Nafria, J.,Nehme, R.,Edwards, P.,Tate, C.G. (deposition date: 2018-04-05, release date: 2018-06-20, Last modification date: 2019-12-11)

• Primary citation: Garcia-Nafria, J.,Nehme, R.,Edwards, P.C.,Tate, C.G.; Cryo-EM structure of the serotonin 5-HT1Breceptor coupled to heterotrimeric Go.; Nature, 558:620-623, 2018; PubMed: 29925951; DOI: 10.1038/s41586-018-0241-9

Experimental method

ELECTRON MICROSCOPY (3.78 Å)