8WNB
 
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8XP9
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8XPA
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8XPB
 | | Crystal structure of d(ACGCCGT/ACGGCGT) in complex with Echinomycin | | Descriptor: | 2-CARBOXYQUINOXALINE, DNA (5'-D(P*AP*CP*GP*CP*CP*GP*T)-3'), DNA (5'-D(P*AP*CP*GP*GP*CP*GP*T)-3'), ... | | Authors: | Hou, M.H, Huang, H.T, Lin, S.M, Neidle, S. | | Deposit date: | 2024-01-03 | | Release date: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of d(ACGCCGT/ACGGCGT) in complex with Echinomycin
To Be Published
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8XP8
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1MNV
 | | Actinomycin D binding to ATGCTGCAT | | Descriptor: | 5'-D(*AP*TP*GP*CP*TP*GP*CP*AP*T)-3', ACTINOMYCIN D | | Authors: | Hou, M.-H, Robinson, H, Gao, Y.-G, Wang, A.H.-J. | | Deposit date: | 2002-09-06 | | Release date: | 2002-11-22 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal Structure of Actinomycin D Bound to the Ctg Triplet Repeat Sequences Linked to Neurological Diseases
Nucleic Acids Res., 30, 2002
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1VAQ
 | | Crystal structure of the Mg2+-(chromomycin A3)2-d(TTGGCCAA)2 complex reveals GGCC binding specificity of the drug dimer chelated by metal ion | | Descriptor: | (1S)-5-deoxy-1-O-methyl-1-C-[(2R,3S)-3,5,7,10-tetrahydroxy-6-methyl-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl]-D-xylulose, 2,6-dideoxy-4-O-methyl-alpha-D-galactopyranose-(1-3)-(2R,3R,6R)-6-hydroxy-2-methyltetrahydro-2H-pyran-3-yl acetate, 3-C-methyl-4-O-acetyl-alpha-L-Olivopyranose-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol, ... | | Authors: | Hou, M.H, Robinson, H, Gao, Y.G, Wang, A.H.-J. | | Deposit date: | 2004-02-19 | | Release date: | 2004-06-22 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of the [Mg2+-(chromomycin A3)2]-d(TTGGCCAA)2 complex reveals GGCC binding specificity of the drug dimer chelated by a metal ion
Nucleic Acids Res., 32, 2004
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5YTZ
 | | Crystal structure of echinomycin-d(ACGTCGT)2 complex | | Descriptor: | 2-CARBOXYQUINOXALINE, DNA (5'-D(P*AP*CP*GP*TP*CP*GP*(UD))-3'), Echinomycin, ... | | Authors: | Hou, M.H, Wu, P.C, Kao, Y.F. | | Deposit date: | 2017-11-20 | | Release date: | 2018-05-23 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Cooperative recognition of T:T mismatch by echinomycin causes structural distortions in DNA duplex
Nucleic Acids Res., 46, 2018
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5YZE
 | | Crystal structure of the [Co2+-(chromomycin A3)2]-d(CCG)3 complex | | Descriptor: | (1S)-5-deoxy-1-O-methyl-1-C-[(2R,3S)-3,5,7,10-tetrahydroxy-6-methyl-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl]-D-xylulose, 2,6-dideoxy-4-O-methyl-alpha-D-galactopyranose-(1-3)-(2R,3R,6R)-6-hydroxy-2-methyltetrahydro-2H-pyran-3-yl acetate, 3-C-methyl-4-O-acetyl-alpha-L-Olivopyranose-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol, ... | | Authors: | Hou, M.H, Chen, Y.W, Wu, P.C, Satange, R.B. | | Deposit date: | 2017-12-14 | | Release date: | 2018-10-17 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | CoII(Chromomycin)2 Complex Induces a Conformational Change of CCG Repeats from i-Motif to Base-Extruded DNA Duplex
Int J Mol Sci, 19, 2018
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5YTY
 | | Crystal structure of echinomycin-d(ACGACGT/ACGTCGT) complex | | Descriptor: | 2-CARBOXYQUINOXALINE, DNA (5'-D(P*AP*CP*GP*AP*CP*GP*T)-3'), DNA (5'-D(P*AP*CP*GP*TP*CP*GP*T)-3'), ... | | Authors: | Hou, M.H, Wu, P.C, Kao, Y.F. | | Deposit date: | 2017-11-20 | | Release date: | 2018-05-23 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.58 Å) | | Cite: | Cooperative recognition of T:T mismatch by echinomycin causes structural distortions in DNA duplex
Nucleic Acids Res., 46, 2018
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5ZT2
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6KL5
 | | Structure of The N-terminal domain of Middle East respiratory syndrome coronavirus Nucleocapsid Protein complexed with Benzyl 2-(Hydroxymethyl)-1-Indolinecarboxylate | | Descriptor: | (phenylmethyl) (2S)-2-(hydroxymethyl)-2,3-dihydroindole-1-carboxylate, Nucleoprotein | | Authors: | Hou, M.H, Lin, S.M, Hsu, J.N, Wang, Y.S. | | Deposit date: | 2019-07-29 | | Release date: | 2020-03-25 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.09 Å) | | Cite: | Structure-Based Stabilization of Non-native Protein-Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design.
J.Med.Chem., 63, 2020
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6KL6
 | | Crystal structure of MERS-CoV N-NTD complexed with 5-Benzyloxygramine | | Descriptor: | N,N-dimethyl-1-(5-phenylmethoxy-1H-indol-3-yl)methanamine, Nucleoprotein | | Authors: | Hou, M.H, Lin, S.M, Wang, Y.S, Hsu, J.N. | | Deposit date: | 2019-07-29 | | Release date: | 2020-03-25 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.77 Å) | | Cite: | Structure-Based Stabilization of Non-native Protein-Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design.
J.Med.Chem., 63, 2020
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6KL2
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6M5J
 | | U shaped head to head four-way junction in d(TTCTGCTGCTGAA/TTCTGCAGCTGAA) sequence | | Descriptor: | COBALT (II) ION, DNA (5'-D(P*TP*TP*CP*TP*GP*CP*AP*GP*CP*TP*GP*AP*A)-3'), DNA (5'-D(P*TP*TP*CP*TP*GP*CP*TP*GP*CP*TP*GP*AP*A)-3'), ... | | Authors: | Hou, M.H, Chien, C.M, Satange, R.B. | | Deposit date: | 2020-03-11 | | Release date: | 2020-07-15 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structural Basis for Targeting T:T Mismatch with Triaminotriazine-Acridine Conjugate Induces a U-Shaped Head-to-Head Four-Way Junction in CTG Repeat DNA.
J.Am.Chem.Soc., 142, 2020
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6M4T
 | | U shaped head to head four-way junction in d(TTCTGCTGCTGAA) sequence | | Descriptor: | COBALT (II) ION, DNA (5'-D(P*(UD)P*TP*CP*TP*GP*CP*TP*GP*CP*TP*GP*AP*A)-3'), N4-[4-[(6-chloranyl-2-methoxy-acridin-9-yl)amino]butyl]-1,3,5-triazine-2,4,6-triamine | | Authors: | Hou, M.H, Chien, C.M, Satange, R.B, Wu, P.C. | | Deposit date: | 2020-03-09 | | Release date: | 2020-07-15 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Structural Basis for Targeting T:T Mismatch with Triaminotriazine-Acridine Conjugate Induces a U-Shaped Head-to-Head Four-Way Junction in CTG Repeat DNA.
J.Am.Chem.Soc., 142, 2020
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6L76
 | | Crystal structure of the Ni(II)(Chro)2-d(TTGGGCCGAA/TTCGGCCCAA) complex at 2.94 angstrom resolution | | Descriptor: | (1S)-5-deoxy-1-O-methyl-1-C-[(2R,3S)-3,5,7,10-tetrahydroxy-6-methyl-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl]-D-xylulose, 2,6-dideoxy-4-O-methyl-alpha-D-galactopyranose-(1-3)-(2R,3R,6R)-6-hydroxy-2-methyltetrahydro-2H-pyran-3-yl acetate, 3-C-methyl-4-O-acetyl-alpha-L-Olivopyranose-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol, ... | | Authors: | Hou, M.H, Jhan, C.R, Satange, R.B, Lin, S.M. | | Deposit date: | 2019-10-31 | | Release date: | 2021-01-13 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.94 Å) | | Cite: | Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction.
Nucleic Acids Res., 49, 2021
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6LNN
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6LZ6
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6LZ8
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5DEV
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6L75
 | | Crystal structure of d(GTGGGCCGAC)2 DNA duplex | | Descriptor: | DNA (5'-D(P*GP*TP*GP*GP*GP*CP*CP*GP*AP*C)-3') | | Authors: | Hou, M.H, Satange, R.B, Zeng, J.Y. | | Deposit date: | 2019-10-31 | | Release date: | 2021-01-13 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.578 Å) | | Cite: | Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction.
Nucleic Acids Res., 49, 2021
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7DYD
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4WJA
 | | Crystal Structure of PAXX | | Descriptor: | Uncharacterized protein C9orf142 | | Authors: | Xing, M, Yang, M, Huo, W, Feng, F, Wei, L, Ning, S, Yan, Z, Li, W, Wang, Q, Hou, M, Dong, C, Guo, R, Gao, G, Ji, J, Lan, L, Liang, H, Xu, D. | | Deposit date: | 2014-09-29 | | Release date: | 2015-03-11 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway.
Nat Commun, 6, 2015
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7BPV
 | | r(GUGGGCCGAC)/d(GTCGGCCCAC) hybrid duplex structure | | Descriptor: | DNA (5'-D(P*GP*TP*CP*GP*GP*CP*CP*CP*AP*C)-3'), RNA (5'-R(P*GP*UP*GP*GP*GP*CP*CP*GP*AP*C)-3'), SULFATE ION | | Authors: | Wang, S.C, Satange, R.B, Hou, M.H. | | Deposit date: | 2020-03-23 | | Release date: | 2021-03-03 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.781 Å) | | Cite: | Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction.
Nucleic Acids Res., 49, 2021
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