1INR
 
 | | CYTOKINE SYNTHESIS | | Descriptor: | INTERLEUKIN-10 | | Authors: | Walter, M.R. | | Deposit date: | 1995-07-31 | | Release date: | 1996-10-14 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of interleukin 10 reveals an interferon gamma-like fold.
Biochemistry, 34, 1995
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2INT
 | | CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-4 | | Descriptor: | INTERLEUKIN-4 | | Authors: | Walter, M.R, Cook, W.J, Zhao, B.G, Cameron Junior, R, Ealick, S.E, Walter Junior, R.L, Reichert, P, Nagabhushan, T.L, Trotta, P.P, Bugg, C.E. | | Deposit date: | 1993-07-22 | | Release date: | 1994-01-31 | | Last modified: | 2019-08-14 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Crystal structure of recombinant human interleukin-4.
J.Biol.Chem., 267, 1992
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1CSG
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1TPT
 | | THREE-DIMENSIONAL STRUCTURE OF THYMIDINE PHOSPHORYLASE FROM ESCHERICHIA COLI AT 2.8 ANGSTROMS RESOLUTION | | Descriptor: | SULFATE ION, THYMIDINE PHOSPHORYLASE, THYMINE | | Authors: | Walter, M.R, Cook, W.J, Cole, L.B, Short, S.A, Koszalka, G.W, Krenitsky, T.A, Ealick, S.E. | | Deposit date: | 1990-06-14 | | Release date: | 1991-07-15 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Three-dimensional structure of thymidine phosphorylase from Escherichia coli at 2.8 A resolution.
J.Biol.Chem., 265, 1990
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1RH2
 | | RECOMBINANT HUMAN INTERFERON-ALPHA 2B | | Descriptor: | INTERFERON-ALPHA 2B, ZINC ION | | Authors: | Walter, M.R. | | Deposit date: | 1996-11-07 | | Release date: | 1997-11-12 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography.
Structure, 4, 1996
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3BES
 | | Structure of a Poxvirus ifngbp/ifng Complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interferon gamma, Interferon-gamma binding protein C4R, ... | | Authors: | Nuara, A.A, Walter, M.R. | | Deposit date: | 2007-11-20 | | Release date: | 2008-02-12 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure and mechanism of IFN-gamma antagonism by an orthopoxvirus IFN-gamma-binding protein.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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1LK3
 | | ENGINEERED HUMAN INTERLEUKIN-10 MONOMER COMPLEXED TO 9D7 FAB FRAGMENT | | Descriptor: | 9D7 Heavy Chain, 9D7 Light Chain, Interleukin-10 | | Authors: | Josephson, K, Jones, B.C, Walter, L.J, DiGiacomo, R, Indelicato, S.R, Walter, M.R. | | Deposit date: | 2002-04-23 | | Release date: | 2002-07-17 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Noncompetitive antibody neutralization of IL-10 revealed by protein engineering and x-ray crystallography.
Structure, 10, 2002
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3DGC
 | | Structure of IL-22/IL-22R1 | | Descriptor: | ACETATE ION, CHLORIDE ION, Interleukin-22, ... | | Authors: | Jones, B.C, Logsdon, N.J, Walter, M.R. | | Deposit date: | 2008-06-13 | | Release date: | 2008-07-15 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of IL-22 Bound to Its High-Affinity IL-22R1 Chain.
Structure, 16, 2008
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8FAX
 | | Fab 1249A8-MERS Stem Helix Complex | | Descriptor: | 1249A8-HC, 1249A8-LC, CHLORIDE ION, ... | | Authors: | Deshpande, A, Schormann, N, Piepenbrink, M.S, Martinez-Sobrido, L, Kobie, J.J, Walter, M.R. | | Deposit date: | 2022-11-28 | | Release date: | 2023-05-03 | | Last modified: | 2023-07-19 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure and epitope of a neutralizing monoclonal antibody that targets the stem helix of beta coronaviruses.
Febs J., 290, 2023
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3LQM
 | | Structure of the IL-10R2 Common Chain | | Descriptor: | GLYCEROL, Interleukin-10 receptor subunit beta, SULFATE ION | | Authors: | Yoon, S.I, Walter, M.R. | | Deposit date: | 2010-02-09 | | Release date: | 2010-05-26 | | Last modified: | 2021-10-13 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Structure and mechanism of receptor sharing by the IL-10R2 common chain.
Structure, 18, 2010
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4DOH
 | | IL20/IL201/IL20R2 Ternary Complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-20, Interleukin-20 receptor subunit alpha, ... | | Authors: | Logsdon, N.J, Walter, M.R. | | Deposit date: | 2012-02-09 | | Release date: | 2012-07-18 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines.
Proc.Natl.Acad.Sci.USA, 109, 2012
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1B5L
 | | OVINE INTERFERON TAU | | Descriptor: | INTERFERON TAU, SULFATE ION | | Authors: | Radhakrishnan, R, Walter, L.J, Subramaniam, P.S, Johnson, H.J, Walter, M.R. | | Deposit date: | 1999-01-07 | | Release date: | 1999-05-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure of ovine interferon-tau at 2.1 A resolution.
J.Mol.Biol., 286, 1999
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1CTR
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1AZY
 | | STRUCTURAL AND THEORETICAL STUDIES SUGGEST DOMAIN MOVEMENT PRODUCES AN ACTIVE CONFORMATION OF THYMIDINE PHOSPHORYLASE | | Descriptor: | THYMIDINE PHOSPHORYLASE | | Authors: | Pugmire, M.J, Cook, W.J, Jasanoff, A, Walter, M.R, Ealick, S.E. | | Deposit date: | 1997-11-24 | | Release date: | 1999-01-13 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural and theoretical studies suggest domain movement produces an active conformation of thymidine phosphorylase.
J.Mol.Biol., 281, 1998
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2TPT
 | | STRUCTURAL AND THEORETICAL STUDIES SUGGEST DOMAIN MOVEMENT PRODUCES AN ACTIVE CONFORMATION OF THYMIDINE PHOSPHORYLASE | | Descriptor: | SULFATE ION, THYMIDINE PHOSPHORYLASE | | Authors: | Pugmire, M.J, Cook, W.J, Jasanoff, A, Walter, M.R, Ealick, S.E. | | Deposit date: | 1997-11-24 | | Release date: | 1999-03-02 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural and theoretical studies suggest domain movement produces an active conformation of thymidine phosphorylase.
J.Mol.Biol., 281, 1998
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1J7V
 | | HUMAN IL-10 / IL-10R1 COMPLEX | | Descriptor: | INTERLEUKIN-10, INTERLEUKIN-10 RECEPTOR ALPHA CHAIN | | Authors: | Josephson, K, Logsdon, N, Walter, M.R. | | Deposit date: | 2001-05-18 | | Release date: | 2001-09-19 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site.
Immunity, 15, 2001
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1LQS
 | | CRYSTAL STRUCTURE OF HUMAN CYTOMEGALOVIRUS IL-10 BOUND TO SOLUBLE HUMAN IL-10R1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, INTERLEUKIN-10 RECEPTOR ALPHA CHAIN, INTERLEUKIN-10-LIKE PROTEIN | | Authors: | Jones, B.C, Logsdon, N.J, Josephson, K, Cook, J, Barry, P.A, Walter, M.R. | | Deposit date: | 2002-05-13 | | Release date: | 2002-07-17 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1.
Proc.Natl.Acad.Sci.USA, 99, 2002
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1OTP
 | | STRUCTURAL AND THEORETICAL STUDIES SUGGEST DOMAIN MOVEMENT PRODUCES AN ACTIVE CONFORMATION OF THYMIDINE PHOSPHORYLASE | | Descriptor: | THYMIDINE PHOSPHORYLASE | | Authors: | Pugmire, M.J, Cook, W.J, Jasanoff, A, Walter, M.R, Ealick, S.E. | | Deposit date: | 1997-11-09 | | Release date: | 1998-12-09 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural and theoretical studies suggest domain movement produces an active conformation of thymidine phosphorylase.
J.Mol.Biol., 281, 1998
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1EKU
 | | CRYSTAL STRUCTURE OF A BIOLOGICALLY ACTIVE SINGLE CHAIN MUTANT OF HUMAN IFN-GAMMA | | Descriptor: | Interferon gamma, SULFATE ION | | Authors: | Landar, A, Curry, B, Parker, M.H, DiGiacomo, R, Indelicato, S.R, Walter, M.R. | | Deposit date: | 2000-03-09 | | Release date: | 2000-09-01 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Design, characterization, and structure of a biologically active single-chain mutant of human IFN-gamma.
J.Mol.Biol., 299, 2000
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1Y6M
 | | Crystal structure of Epstein-Barr virus IL-10 complexed with the soluble IL-10R1 chain | | Descriptor: | Interleukin-10 receptor alpha chain, Viral interleukin-10 homolog | | Authors: | Yoon, S.I, Jones, B.C, Logsdon, N.J, Walter, M.R. | | Deposit date: | 2004-12-06 | | Release date: | 2005-05-03 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain.
Structure, 13, 2005
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1Y6K
 | | Crystal structure of human IL-10 complexed with the soluble IL-10R1 chain | | Descriptor: | Interleukin-10, Interleukin-10 receptor alpha chain | | Authors: | Yoon, S.I, Jones, B.C, Josepson, K, Logsdon, N.J, Walter, M.R. | | Deposit date: | 2004-12-06 | | Release date: | 2005-12-20 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.52 Å) | | Cite: | Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain.
Structure, 13, 2005
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1Y6N
 | | Crystal structure of Epstein-Barr virus IL-10 mutant (A87I) complexed with the soluble IL-10R1 chain | | Descriptor: | Interleukin-10 receptor alpha chain, Viral interleukin-10 homolog | | Authors: | Yoon, S.I, Jones, B.C, Logsdon, N.J, Walter, M.R. | | Deposit date: | 2004-12-06 | | Release date: | 2005-05-03 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain.
Structure, 13, 2005
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1YKB
 | | Crystal Structure of Insect Cell Expressed IL-22 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Xu, T, Logsdon, N.J, Walter, M.R. | | Deposit date: | 2005-01-17 | | Release date: | 2005-07-12 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure of insect-cell-derived IL-22.
Acta Crystallogr.,Sect.D, 61, 2005
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2H24
 | | Crystal structure of human IL-10 | | Descriptor: | Interleukin-10 | | Authors: | Yoon, S.I, Walter, M.R. | | Deposit date: | 2006-05-18 | | Release date: | 2006-10-17 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex.
J.Biol.Chem., 281, 2006
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1A29
 | | CALMODULIN COMPLEXED WITH TRIFLUOPERAZINE (1:2 COMPLEX) | | Descriptor: | 10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE, CALCIUM ION, CALMODULIN | | Authors: | Bocskei, Zs, Harmat, V, Vertessy, B.G, Ovadi, J, Naray-Szabo, G. | | Deposit date: | 1998-01-19 | | Release date: | 1998-09-16 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.74 Å) | | Cite: | Simultaneous binding of drugs with different chemical structures to Ca2+-calmodulin: crystallographic and spectroscopic studies.
Biochemistry, 37, 1998
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