6H22

Crystal structure of Mdm2 bound to a stapled peptide

Summary for 6H22

Entry DOI	10.2210/pdb6h22/pdb
Descriptor	E3 ubiquitin-protein ligase Mdm2, Stapled peptide, 12-(dimethylamino)-3,10-diethyl-N,N,N-trimethyl-3,10-dihydrodibenzo[3,4:7,8]cycloocta[1,2-d:5,6-d']bis([1,2,3]triazole)-5-aminium, ... (4 entities in total)
Functional Keywords	stapled peptide, inhibitor, e3-ligase, ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	25898.22
Authors	Wang, X.,Sharma, K.,Spring, D.R.,Hyvonen, M. (deposition date: 2018-07-12, release date: 2019-07-31, Last modification date: 2019-09-11)
Primary citation	Sharma, K.,Strizhak, A.V.,Fowler, E.,Wang, X.,Xu, W.,Hatt Jensen, C.,Wu, Y.,Sore, H.F.,Lau, Y.H.,Hyvonen, M.,Itzhaki, L.S.,Spring, D.R. Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry. Org.Biomol.Chem., 17:8014-8018, 2019 Cited by PubMed: 31418442 DOI: 10.1039/c9ob01745c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.006 Å)

Structure validation