6H22

Crystal structure of Mdm2 bound to a stapled peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle
B	0005634	cellular_component	nucleus
B	0043066	biological_process	negative regulation of apoptotic process
B	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for Ligand NH2 C 13 bound to SER C 12

Chain	Residue
A	GLN24
A	HOH209
C	ALA11
C	SER12

---

site_id	AC2
Number of Residues	3
Details	binding site for Ligand NH2 D 13 bound to SER D 12

Chain	Residue
B	GLN24
D	ALA11
D	SER12

---

site_id	AC3
Number of Residues	5
Details	binding site for Di-peptide ACE C 0 and LEU C 1

Chain	Residue
C	GLU5
C	TYR6
C	GLN9
A	HOH226
C	THR2

---

site_id	AC4
Number of Residues	17
Details	binding site for Di-peptide FL5 C 1001 and ALA C 11

Chain	Residue
A	LYS51
A	PHE55
A	MET62
A	HOH207
B	TYR76
B	PRO89
B	SER90
B	PHE91
C	ALA4
C	GLU5
C	ALA8
C	GLN9
C	LEU10
C	SER12
C	NH213
C	HOH1104
C	HOH1108

---

site_id	AC5
Number of Residues	17
Details	binding site for Di-peptide FL5 C 1001 and ALA C 4

Chain	Residue
A	PHE55
A	MET62
A	HOH207
B	TYR76
B	PRO89
B	SER90
B	PHE91
C	THR2
C	PHE3
C	GLU5
C	TYR6
C	TRP7
C	ALA8
C	ALA11
C	HOH1104
C	HOH1108
C	HOH1109

---

site_id	AC6
Number of Residues	6
Details	binding site for Di-peptide ACE D 0 and LEU D 1

Chain	Residue
A	LYS36
D	THR2
D	GLU5
D	TYR6
D	GLN9
D	HOH1107

---

site_id	AC7
Number of Residues	17
Details	binding site for Di-peptide FL5 D 1001 and ALA D 11

Chain	Residue
A	TYR76
A	PRO89
A	SER90
A	PHE91
B	LYS51
B	PHE55
B	GLN59
B	HOH222
D	ALA4
D	GLU5
D	ALA8
D	GLN9
D	LEU10
D	SER12
D	NH213
D	HOH1103
D	HOH1108

---

site_id	AC8
Number of Residues	17
Details	binding site for Di-peptide FL5 D 1001 and ALA D 4

Chain	Residue
A	TYR76
A	PRO89
A	SER90
A	PHE91
B	PHE55
B	GLN59
B	HOH222
D	THR2
D	PHE3
D	GLU5
D	TYR6
D	TRP7
D	ALA8
D	ALA11
D	HOH1103
D	HOH1108
D	HOH1110

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