4BVG
CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH NATIVE ALKYLIMIDATE FORMED FROM ACETYL-LYSINE ACS2-PEPTIDE CRYSTALLIZED IN PRESENCE OF THE INHIBITOR EX-527
Summary for 4BVG
Entry DOI | 10.2210/pdb4bvg/pdb |
Related | 4BUZ 4BV2 4BV3 4BVB 4BVE 4BVF 4BVH |
Descriptor | NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL, ACETYL-COENZYME A SYNTHETASE 2-LIKE, MITOCHONDRIAL, 1,2-ETHANEDIOL, ... (9 entities in total) |
Functional Keywords | hydrolase-ligase complex, nad-dependent deacetylase, native intermediate, hydrolase/ligase |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 2 |
Total formula weight | 34367.48 |
Authors | Nguyen, G.T.T.,Gertz, M.,Weyand, M.,Steegborn, C. (deposition date: 2013-06-25, release date: 2013-07-17, Last modification date: 2023-12-20) |
Primary citation | Gertz, M.,Fischer, F.,Nguyen, G.T.,Lakshminarasimhan, M.,Schutkowski, M.,Weyand, M.,Steegborn, C. Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism. Proc. Natl. Acad. Sci. U.S.A., 110:E2772-E2781, 2013 Cited by PubMed: 23840057DOI: 10.1073/pnas.1303628110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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