4BV2

CRYSTAL STRUCTURE OF SIR2 IN COMPLEX WITH THE INHIBITOR EX-527, 2'-O-ACETYL-ADP-RIBOSE AND DEACETYLATED P53-PEPTIDE

Summary for 4BV2

Entry DOI	10.2210/pdb4bv2/pdb
Related	4BUZ 4BV3 4BVB 4BVE 4BVF 4BVG 4BVH
Descriptor	NAD-DEPENDENT PROTEIN DEACETYLASE, CELLULAR TUMOR ANTIGEN P53, ZINC ION, ... (5 entities in total)
Functional Keywords	hydrolase, nad-dependent deacetylase, sirtuin, inhibitor complex, ex-527, acetylated adp-ribose, hydrolase-hydrolase
Biological source	THERMOTOGA MARITIMA More
Cellular location	Cytoplasm (By similarity): Q9WYW0 Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
Total number of polymer chains	4
Total formula weight	60166.32
Authors	Gertz, M.,Weyand, M.,Steegborn, C. (deposition date: 2013-06-24, release date: 2013-07-17, Last modification date: 2023-12-20)
Primary citation	Gertz, M.,Fischer, F.,Nguyen, G.T.T.,Lakshminarasimhan, M.,Schutkowski, M.,Weyand, M.,Steegborn, C. Ex-527 Inhibits Sirtuins by Exploiting Their Unique Nad+-Dependent Deacetylation Mechanism Proc.Natl.Acad.Sci.USA, 110:E2772-, 2013 Cited by PubMed: 23840057 DOI: 10.1073/PNAS.1303628110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation