4BVF

CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH THIOALKYLIMIDATE FORMED FROM THIO-ACETYL-LYSINE ACS2-PEPTIDE CRYSTALLIZED IN PRESENCE OF THE INHIBITOR EX-527

Summary for 4BVF

Entry DOI	10.2210/pdb4bvf/pdb
Related	3GLT 4BUZ 4BV2 4BV3 4BVB 4BVE 4BVG 4BVH
Descriptor	NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL, ACETYL-COENZYME A SYNTHETASE 2-LIKE, MITOCHONDRIAL, ZINC ION, ... (5 entities in total)
Functional Keywords	hydrolase-ligase complex, thio-intermediate, hydrolase-hydrolase, hydrolase/ligase
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Mitochondrion matrix: Q9NTG7 Q9NUB1
Total number of polymer chains	2
Total formula weight	33417.58
Authors	Gertz, M.,Weyand, M.,Steegborn, C. (deposition date: 2013-06-25, release date: 2013-07-17, Last modification date: 2023-12-20)
Primary citation	Gertz, M.,Fischer, F.,Nguyen, G.T.T.,Lakshminarasimhan, M.,Schutkowski, M.,Weyand, M.,Steegborn, C. Ex-527 Inhibits Sirtuins by Exploiting Their Unique Nad+-Dependent Deacetylation Mechanism Proc.Natl.Acad.Sci.USA, 110:E2772-, 2013 Cited by PubMed: 23840057 DOI: 10.1073/PNAS.1303628110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation