4BVB

CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH THE INHIBITOR EX-527 AND ADP-RIBOSE

Summary for 4BVB

Entry DOI	10.2210/pdb4bvb/pdb
Related	4BUZ 4BV2 4BV3 4BVE 4BVF 4BVG 4BVH
Descriptor	NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL, (1S)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1- carboxamide, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ... (5 entities in total)
Functional Keywords	hydrolase, nad-dependent deacetylase, inhibitor complex, adp-ribose
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Mitochondrion matrix: Q9NTG7
Total number of polymer chains	1
Total formula weight	32357.65
Authors	Gertz, M.,Weyand, M.,Steegborn, C. (deposition date: 2013-06-25, release date: 2013-07-17, Last modification date: 2023-12-20)
Primary citation	Gertz, M.,Fischer, F.,Nguyen, G.T.T.,Lakshminarasimhan, M.,Schutkowski, M.,Weyand, M.,Steegborn, C. Ex-527 Inhibits Sirtuins by Exploiting Their Unique Nad+-Dependent Deacetylation Mechanism Proc.Natl.Acad.Sci.USA, 110:E2772-, 2013 Cited by PubMed: 23840057 DOI: 10.1073/PNAS.1303628110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation