4BV3
CRYSTAL STRUCTURE OF SIRT3 IN COMPLEX WITH THE INHIBITOR EX-527 AND NAD
Summary for 4BV3
| Entry DOI | 10.2210/pdb4bv3/pdb |
| Related | 4BUZ 4BV2 4BVB 4BVE 4BVF 4BVG 4BVH |
| Descriptor | NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ADENOSINE-5-DIPHOSPHORIBOSE, ... (10 entities in total) |
| Functional Keywords | hydrolase, inhibitor |
| Biological source | HOMO SAPIENS (HUMAN) |
| Cellular location | Mitochondrion matrix: Q9NTG7 |
| Total number of polymer chains | 1 |
| Total formula weight | 33325.71 |
| Authors | Gertz, M.,Nguyen, N.T.T.,Weyand, M.,Steegborn, C. (deposition date: 2013-06-24, release date: 2013-07-17, Last modification date: 2023-12-20) |
| Primary citation | Gertz, M.,Fischer, F.,Nguyen, G.T.T.,Lakshminarasimhan, M.,Schutkowski, M.,Weyand, M.,Steegborn, C. Ex-527 Inhibits Sirtuins by Exploiting Their Unique Nad+-Dependent Deacetylation Mechanism Proc.Natl.Acad.Sci.USA, 110:E2772-, 2013 Cited by PubMed: 23840057DOI: 10.1073/PNAS.1303628110 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report
