3EHI

Crystal Structure of Human Thymidyalte Synthase M190K with Loop 181-197 stabilized in the inactive conformation

Summary for 3EHI

• Entry DOI: 10.2210/pdb3ehi/pdb
• Related: 1HVY 1HW3 1YPV 2ONB 2RD8 2RDA 3EGY
• Descriptor: Thymidylate synthase, SULFATE ION, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: methyltransferase, nucleotide biosynthesis, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : P04818
• Total number of polymer chains: 1
• Total formula weight: 36167.35

Authors

Lovelace, L.L.,Gibson, L.M.,Johnson, S.R.,Berger, S.H.,Lebioda, L. (deposition date: 2008-09-12, release date: 2009-08-18, Last modification date: 2023-08-30)

• Primary citation: Lovelace, L.L.,Johnson, S.R.,Gibson, L.M.,Bell, B.J.,Berger, S.H.,Lebioda, L.; Variants of human thymidylate synthase with loop 181-197 stabilized in the inactive conformation.; Protein Sci., 18:1628-1636, 2009; PubMed: 19569192; DOI: 10.1002/pro.171

Experimental method

X-RAY DIFFRACTION (2 Å)