2RDA

Human Thymidylate Synthase Stabilized in Active Conformation by R163K Mutation: Asymmetry and Reactivity of Cys195

Summary for 2RDA

• Entry DOI: 10.2210/pdb2rda/pdb
• Related: 1HVY 2RD8
• Descriptor: Thymidylate synthase, PHOSPHATE ION, BETA-MERCAPTOETHANOL, ... (4 entities in total)
• Functional Keywords: methyl transferase, asymmetric, methyltransferase, nucleotide biosynthesis, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : P04818
• Total number of polymer chains: 6
• Total formula weight: 215040.68

Authors

Gibson, L.M.,Lovelace, L.L.,Lebioda, L. (deposition date: 2007-09-21, release date: 2008-06-10, Last modification date: 2023-08-30)

• Primary citation: Gibson, L.M.,Lovelace, L.L.,Lebioda, L.; The R163K mutant of human thymidylate synthase is stabilized in an active conformation: structural asymmetry and reactivity of cysteine 195.; Biochemistry, 47:4636-4643, 2008; PubMed: 18370400; DOI: 10.1021/bi7019386

Experimental method

X-RAY DIFFRACTION (2.67 Å)