2RD8

Human Thymidylate Synthase Stabilized in Active Conformation by R163K Mutation: Asymmetry and Reactivity of Cys195

Summary for 2RD8

• Entry DOI: 10.2210/pdb2rd8/pdb
• Related: 1HVY 1HW3 1YPV
• Descriptor: Thymidylate synthase, BETA-MERCAPTOETHANOL, PHOSPHATE ION, ... (5 entities in total)
• Functional Keywords: methyl transferase, methyltransferase, nucleotide biosynthesis, transferase
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : P04818 P04818
• Total number of polymer chains: 2
• Total formula weight: 71814.04

Authors

Gibson, L.M.,Lovelace, L.L.,Lebioda, L. (deposition date: 2007-09-21, release date: 2008-05-27, Last modification date: 2023-08-30)

• Primary citation: Gibson, L.M.,Lovelace, L.L.,Lebioda, L.; The R163K Mutant of Human Thymidylate Synthase Is Stabilized in an Active Conformation: Structural Asymmetry and Reactivity of Cysteine 195.; Biochemistry, 47:4636-4643, 2008; PubMed: 18370400; DOI: 10.1021/bi7019386

Experimental method

X-RAY DIFFRACTION (2.5 Å)