1HW3
STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS
Summary for 1HW3
Entry DOI | 10.2210/pdb1hw3/pdb |
Related | 1HW4 |
Descriptor | THYMIDYLATE SYNTHASE, SULFATE ION, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | thymidylate synthase, methyltransferase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 36513.72 |
Authors | Phan, J.,Steadman, J.D.,Koli, S.,Ding, W.C.,Minor, W.,Dunlap, R.B.,Berger, S.H.,Lebioda, L. (deposition date: 2001-01-09, release date: 2001-01-24, Last modification date: 2022-04-13) |
Primary citation | Phan, J.,Steadman, D.J.,Koli, S.,Ding, W.C.,Minor, W.,Dunlap, R.B.,Berger, S.H.,Lebioda, L. Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors. J.Biol.Chem., 276:14170-14177, 2001 Cited by PubMed: 11278511PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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