2ONB

Human Thymidylate Synthase at low salt conditions with PDPA bound

Summary for 2ONB

Entry DOI	10.2210/pdb2onb/pdb
Related	1YPV
Descriptor	Thymidylate synthetase, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	diphosphonic acid, fdump, zd9331, heteroinhibition, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	36429.59
Authors	Lovelace, L.L.,Gibson, L.M.,Lebioda, L. (deposition date: 2007-01-23, release date: 2007-04-10, Last modification date: 2023-08-30)
Primary citation	Lovelace, L.L.,Gibson, L.M.,Lebioda, L. Cooperative Inhibition of Human Thymidylate Synthase by Mixtures of Active Site Binding and Allosteric Inhibitors Biochemistry, 46:2823-2830, 2007 Cited by PubMed: 17297914 DOI: 10.1021/bi061309j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation