2XD6
Hsp90 complexed with a resorcylic acid macrolactone.
Summary for 2XD6
Entry DOI | 10.2210/pdb2xd6/pdb |
Related | 1A4H 1AH6 1AH8 1AM1 1AMW 1BGQ 1HK7 1US7 1USU 1USV 1ZW9 1ZWH 2AKP 2BRC 2BRE 2CG9 2CGE 2CGF 2IWS 2IWU 2IWX 2VLS 2VW5 2VWC 2WEP 2WEQ 2WER |
Descriptor | ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, (5Z)-13-CHLORO-14,16-DIHYDROXY-1,11-DIOXO-3,4,7,8,9,10,11,12-OCTAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-6-CARBALDEHYDE, GLYCEROL, ... (4 entities in total) |
Functional Keywords | chaperone, inhibitor, atpase |
Biological source | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) |
Cellular location | Cytoplasm : P02829 |
Total number of polymer chains | 1 |
Total formula weight | 24943.75 |
Authors | Roe, S.M.,Prodromou, C.,Pearl, L.H.,Moody, C.J. (deposition date: 2010-04-29, release date: 2010-08-11, Last modification date: 2023-12-20) |
Primary citation | Day, J.E.H.,Sharp, S.Y.,Rowlands, M.G.,Aherne, W.,Lewis, W.,Roe, S.M.,Prodromou, C.,Pearl, L.H.,Workman, P.,Moody, C.J. Inhibition of Hsp90 with Resorcylic Acid Macrolactones. Synthesis and Binding Studies. Chemistry, 16:10366-, 2010 Cited by PubMed: 20661961DOI: 10.1002/CHEM.201001119 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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