1ZWH
Yeast Hsp82 in complex with the novel Hsp90 inhibitor Radester amine
Summary for 1ZWH
Entry DOI | 10.2210/pdb1zwh/pdb |
Related | 1A4H 1BGQ 1OSF 1QY8 1U0Z 1YET |
Descriptor | ATP-dependent molecular chaperone HSP82, 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE (3 entities in total) |
Functional Keywords | hsp82, hsp90, grp94, htpg, chaperone, ligand, radicicol, geldanamycin |
Biological source | Saccharomyces cerevisiae (baker's yeast) |
Cellular location | Cytoplasm: P02829 |
Total number of polymer chains | 1 |
Total formula weight | 27442.58 |
Authors | Immormino, R.M.,Blagg, B.S.,Gewirth, D.T. (deposition date: 2005-06-03, release date: 2006-06-13, Last modification date: 2024-02-14) |
Primary citation | Immormino, R.M.,Blagg, B.S.,Gewirth, D.T. Inhibitory Ligands Adopt Different Conformations When Bound to Hsp90 or GRP94: Implications for Paralog-specific Drug Design To be Published, |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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