2CGF

A RADICICOL ANALOGUE BOUND TO THE ATP BINDING SITE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE

Summary for 2CGF

Entry DOI	10.2210/pdb2cgf/pdb
Related	1A4H 1AH6 1AH8 1AM1 1AMW 1BGQ 1HK7 1US7 1USU 1USV 2AKP 2BRC 2BRE 2CG9 2CGE
Descriptor	ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, (5Z)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE (3 entities in total)
Functional Keywords	atp-binding, chaperone, heat shock, inhibitor, multigene family
Biological source	SACCHAROMYCES CEREVISIAE (BAKERS YEAST)
Cellular location	Cytoplasm: P02829
Total number of polymer chains	1
Total formula weight	25837.81
Authors	Roe, S.M.,Prodromou, C.,Pearl, L.H.,Moody, C.J. (deposition date: 2006-03-02, release date: 2006-11-29, Last modification date: 2011-07-13)
Primary citation	Proisy, N.,Sharp, S.Y.,Boxall, K.,Connelly, S.,Roe, S.M.,Prodromou, C.,Slawin, A.M.Z.,Pearl, L.H.,Workman, P.,Moody, C.J. Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol. Chem.Biol., 13:1203-, 2006 Cited by PubMed: 17114002 DOI: 10.1016/J.CHEMBIOL.2006.09.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation