2IWS

Radicicol analogues bound to the ATP site of HSP90

Summary for 2IWS

Entry DOI	10.2210/pdb2iws/pdb
Related	1A4H 1AH6 1AH8 1AM1 1AMW 1BGQ 1HK7 1US7 1USU 1USV 1ZWH 2AKP 2BRC 2BRE 2CG9 2CGE 2CGF 2IWU 2IWX
Descriptor	ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, (5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE (3 entities in total)
Functional Keywords	inhibitor, chaperone, heat shock, atp-binding, multigene family, nucleotide-binding
Biological source	SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)
Total number of polymer chains	1
Total formula weight	24533.34
Authors	Roe, S.M.,Prodromou, C.,Pearl, L.H. (deposition date: 2006-07-04, release date: 2006-11-30, Last modification date: 2023-12-13)
Primary citation	Proisy, N.,Sharp, S.Y.,Boxall, K.,Connelly, S.,Roe, S.M.,Prodromou, C.,Slawin, A.M.Z.,Pearl, L.H.,Workman, P.,Moody, C.J. Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol. Chem.Biol., 13:1203-, 2006 Cited by PubMed: 17114002 DOI: 10.1016/J.CHEMBIOL.2006.09.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation