1ZW9

Yeast HSP82 in complex with the Novel HSP90 Inhibitor 8-(6-Bromo-benzo[1,3]dioxol-5-ylsulfanyl)-9-(3-isopropylamino-propyl)-adenine

Summary for 1ZW9

• Entry DOI: 10.2210/pdb1zw9/pdb
• Related: 1UY6 1UYF 1UYI
• Descriptor: HSP82, 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE (3 entities in total)
• Functional Keywords: hsp82, hsp90, grp94, htpg, chaperone, ligand, adenosine
• Biological source: Saccharomyces cerevisiae (baker's yeast)
• Cellular location: Cytoplasm: P02829
• Total number of polymer chains: 1
• Total formula weight: 27510.14

Authors

Immormino, R.M.,Gewirth, D.T.,Chiosis, G. (deposition date: 2005-06-03, release date: 2006-06-13, Last modification date: 2024-02-14)

• Primary citation: Immormino, R.M.,Gewirth, D.T.,Chiosis, G.; Inhibitory Ligands Adopt Different Conformations When Bound to Hsp90 or GRP94: Implications for Paralog-specific Drug Design; To be Published,

Experimental method

X-RAY DIFFRACTION (1.9 Å)