2VF0

CRYSTAL STRUCTURE OF THE THYMIDYLATE SYNTHASE K48Q COMPLEXED WITH 5NO2DUMP AND BW1843U89

Summary for 2VF0

• Entry DOI: 10.2210/pdb2vf0/pdb
• Related: 1AIQ 1AJM 1AN5 1AOB 1AXW 1BDU 1BID 1BJG 1BQ1 1BQ2 1DDU 1DNA 1EV5 1EV8 1EVF 1EVG 1F4B 1F4C 1F4D 1F4E 1F4F 1F4G 1FFL 1FWM 1JG0 1JTQ 1JTU 1JUT 1KCE 1KZI 1KZJ 1NCE 1QQQ 1SYN 1TDU 1TJS 1TLC 1TLS 1TRG 1TSD 1TSN 1TYS 1ZPR 2A9W 2BBQ 2FTN 2FTO 2FTQ 2G8M 2G8O 2G8X 2KCE 2TSC 2VET 3B5B 3TMS
• Descriptor: THYMIDYLATE SYNTHASE, 2'-DEOXY-5-NITROURIDINE 5'-MONOPHOSPHATE, S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN-9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID, ... (5 entities in total)
• Functional Keywords: nucleotide biosynthesis, substrate anologue, antifolate binding, rna-binding, transferase, methyltransferase, repressor, bw1843u89, cytoplasm, 5-no2-dump, thymidylate synthase, translation regulation
• Biological source: ESCHERICHIA COLI
• Cellular location: Cytoplasm : P0A884
• Total number of polymer chains: 2
• Total formula weight: 62924.69

Authors

Sotelo-Mundo, R.R.,Arreola, R.,Maley, F.,Montfort, W.R. (deposition date: 2007-10-27, release date: 2007-12-04, Last modification date: 2023-12-13)

• Primary citation: Arvizu-Flores, A.A.,Sugich-Miranda, R.,Arreola, R.,Garcia-Orozco, K.D.,Velazquez-Contreras, E.F.,Montfort, W.R.,Maley, F.,Sotelo-Mundo, R.R.; Role of an Invariant Lysine Residue in Folate Binding on Escherichia Coli Thymidylate Synthase: Calorimetric and Crystallographic Analysis of the K48Q Mutant.; Int.J.Biochem.Cell Biol., 40:2206-, 2008; PubMed: 18403248; DOI: 10.1016/J.BIOCEL.2008.02.025

Experimental method

X-RAY DIFFRACTION (3 Å)