1BJG
D221(169)N MUTANT DOES NOT PROMOTE OPENING OF THE COFACTOR IMIDAZOLIDINE RING
Summary for 1BJG
Entry DOI | 10.2210/pdb1bjg/pdb |
Descriptor | THYMIDYLATE SYNTHASE, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 5,10-METHYLENE-6-HYDROFOLIC ACID, ... (4 entities in total) |
Functional Keywords | transferase, active site mutant, reaction intermediate methyltransferase |
Biological source | Escherichia coli |
Cellular location | Cytoplasm: P0A884 |
Total number of polymer chains | 1 |
Total formula weight | 31340.27 |
Authors | Sage, C.R.,Michelitsch, M.D.,Finer-Moore, J.,Stroud, R.M. (deposition date: 1998-06-25, release date: 1998-11-04, Last modification date: 2024-04-03) |
Primary citation | Sage, C.R.,Michelitsch, M.D.,Stout, T.J.,Biermann, D.,Nissen, R.,Finer-Moore, J.,Stroud, R.M. D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine. Biochemistry, 37:13893-13901, 1998 Cited by PubMed: 9753479DOI: 10.1021/bi9810510 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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