1TSD

THYMIDYLATE SYNTHASE COMPLEX WITH 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) AND FOLATE ANALOG 1843U89

Summary for 1TSD

Entry DOI	10.2210/pdb1tsd/pdb
Descriptor	THYMIDYLATE SYNTHASE, BETA-MERCAPTOETHANOL, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (5 entities in total)
Functional Keywords	dump, 1843u89, transferase (methyltransferase)
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	62860.96
Authors	Weichsel, A.,Montfort, W.R. (deposition date: 1995-08-15, release date: 1996-01-29, Last modification date: 2018-04-18)
Primary citation	Weichsel, A.,Montfort, W.R. Ligand-induced distortion of an active site in thymidylate synthase upon binding anticancer drug 1843U89. Nat.Struct.Biol., 2:1095-1101, 1995 Cited by PubMed: 8846221 DOI: 10.1038/nsb1295-1095 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation