6NNR
high-resolution structure of wild-type E. coli thymidylate synthase
Replaces: 4KNZReplaces: 2G8OReplaces: 4IW5Summary for 6NNR
Entry DOI | 10.2210/pdb6nnr/pdb |
Descriptor | Thymidylate synthase, 2'-deoxy-5'-uridylic acid, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (6 entities in total) |
Functional Keywords | nucleotide synthesis, hydride transfer, methyl transfer, cancer drug target, transferase |
Biological source | Escherichia coli (strain K12) |
Total number of polymer chains | 2 |
Total formula weight | 63194.27 |
Authors | Stroud, R.M.,Finer-Moore, J. (deposition date: 2019-01-15, release date: 2019-01-30, Last modification date: 2023-10-11) |
Primary citation | Wang, Z.,Sapienza, P.J.,Abeysinghe, T.,Luzum, C.,Lee, A.L.,Finer-Moore, J.S.,Stroud, R.M.,Kohen, A. Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site. J. Am. Chem. Soc., 135:7583-7592, 2013 Cited by PubMed: 23611499DOI: 10.1021/ja400761x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.05 Å) |
Structure validation
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