1TLC

THYMIDYLATE SYNTHASE COMPLEXED WITH DGMP AND FOLATE ANALOG 1843U89

Summary for 1TLC

• Entry DOI: 10.2210/pdb1tlc/pdb
• Descriptor: THYMIDYLATE SYNTHASE, 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN-9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC ACID, ... (4 entities in total)
• Functional Keywords: methyltransferase
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 62782.77

Authors

Weichsel, A.,Montfort, W.R.,Ciesla, J.,Maley, F. (deposition date: 1995-03-07, release date: 1995-06-03, Last modification date: 2018-04-18)

• Primary citation: Weichsel, A.,Montfort, W.R.,Ciesla, J.,Maley, F.; Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89.; Proc.Natl.Acad.Sci.USA, 92:3493-3497, 1995; PubMed: 7724588; DOI: 10.1073/pnas.92.8.3493

Experimental method

X-RAY DIFFRACTION (2.1 Å)