1H23
Structure of acetylcholinesterase (E.C. 3.1.1.7) complexed with (S,S)-(-)-bis(12)-hupyridone at 2.15A resolution
1H23 の概要
エントリーDOI | 10.2210/pdb1h23/pdb |
関連するPDBエントリー | 1ACJ 1ACL 1AMN 1AX9 1CFJ 1DX6 1E3Q 1E66 1EA5 1EEA 1EVE 1FSS 1GPK 1GPN 1GQR 1GQS 1H22 1HBJ 1JJB 1OCE 1QID 1QIE 1QIF 1QIG 1QIH 1QII 1QIJ 1QIK 1QIM 1QTI 1SOM 1VOT 1VXO 1VXR 2ACE 2ACK 2DFP 3ACE 4ACE |
分子名称 | ACETYLCHOLINESTERASE, (S,S)-(-)-N,N'-DI-5'-[5',6',7',8'-TETRAHYDRO- 2'(1'H)-QUINOLYNYL]-1,12-DIAMINODODECANE DIHYDROCHLORIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
機能のキーワード | serine hydrolase, acetylcholinesterase, neurotransmitter cleavage, alzheimer's disease, bivalent ligand, dual-site binding, inhibitor, huperzine a, hydrolase, serine esterase synapse, membrane, nerve, muscle, gpi-anchor neurotransmitter degradation, glycoprotein, bis(12)-hupyrid |
由来する生物種 | TORPEDO CALIFORNICA (PACIFIC ELECTRIC RAY) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 62262.22 |
構造登録者 | Wong, D.M.,Greenblatt, H.M.,Carlier, P.R.,Han, Y.F.,Pang, Y.P.,Silman, I.,Sussman, J.L. (登録日: 2002-07-30, 公開日: 2002-12-23, 最終更新日: 2023-12-13) |
主引用文献 | Wong, D.M.,Greenblatt, H.M.,Dvir, H.,Carlier, P.R.,Han, Y.F.,Pang, Y.P.,Silman, I.,Sussman, J.L. Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity J.Am.Chem.Soc., 125:363-, 2003 Cited by PubMed: 12517147DOI: 10.1021/JA021111W 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.15 Å) |
構造検証レポート
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