Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1GPK

Structure of Acetylcholinesterase Complex with (+)-Huperzine A at 2.1A Resolution

Summary for 1GPK
Entry DOI10.2210/pdb1gpk/pdb
Related1ACJ 1ACL 1AMN 1AX9 1CFJ 1DX6 1E3Q 1E66 1EA5 1EEA 1EVE 1FSS 1HBJ 1OCE 1QID 1QIE 1QIF 1QIG 1QIH 1QII 1QIJ 1QIK 1QIM 1QTI 1SOM 1VOT 1VXO 1VXR 2ACE 2ACK 2DFP
DescriptorACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywordshydrolase, cholinesterase, huperzine a, alzheimer's disease
Biological sourceTORPEDO CALIFORNICA (PACIFIC ELECTRIC RAY)
Cellular locationIsoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058
Total number of polymer chains1
Total formula weight61845.65
Authors
Dvir, H.,Harel, M.,Chetrit, M.,Silman, I.,Sussman, J.L. (deposition date: 2001-11-05, release date: 2002-08-29, Last modification date: 2023-12-13)
Primary citationDvir, H.,Jiang, H.L.,Wong, D.M.,Harel, M.,Chetrit, M.,He, X.C.,Jin, G.Y.,Yu, G.L.,Tang, X.C.,Silman, I.,Bai, D.L.,Sussman, J.L.
X-Ray Structures of Torpedo Californica Acetylcholinesterase Complexed with (+)-Huperzine a and (-)-Huperzine B: Structural Evidence for an Active Site Rearrangement
Biochemistry, 41:10810-, 2002
Cited by
PubMed: 12196020
DOI: 10.1021/BI020151+
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon