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1QTI

Acetylcholinesterase (E.C.3.1.1.7)

Summary for 1QTI
Entry DOI10.2210/pdb1qti/pdb
Related1ACJ 1ACL 1AMN 1CFJ 1EVE 1OCE 1VOT 2ACE 2ACK
DescriptorACETYLCHOLINESTERASE, (-)-GALANTHAMINE (3 entities in total)
Functional Keywordsalzheimer's disease, drug, serine hydrolase, alpha/beta hydrolase, neurotransmitter cleaveage, catalytic triad, hydrolase
Biological sourceTorpedo californica (Pacific electric ray)
Cellular locationIsoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058
Total number of polymer chains1
Total formula weight61023.87
Authors
Bartolucci, C.,Perola, E.,Pilger, C.,Fels, G.,Lamba, D. (deposition date: 1999-06-28, release date: 1999-12-29, Last modification date: 2021-06-02)
Primary citationBartolucci, C.,Perola, E.,Pilger, C.,Fels, G.,Lamba, D.
Three-dimensional structure of a complex of galanthamine (Nivalin) with acetylcholinesterase from Torpedo californica: implications for the design of new anti-Alzheimer drugs
Proteins, 42:182-191, 2001
Cited by
PubMed: 11119642
DOI: 10.1002/1097-0134(20010201)42:2<182::AID-PROT50>3.0.CO;2-1
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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