5I5K
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STRUCTURE OF COMPLEMENT C5 IN COMPLEX WITH ECULIZUMAB
Descriptor:Complement C5, Eculizumab heavy chain (variable domain), Eculizumab light chain (variable domain)
Authors:Schatz-Jakobsen, J.A., Andersen, G.R.
Deposit date:2016-02-15
Release date:2016-03-16
Modification date:2016-06-29
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Structural Basis for Eculizumab-Mediated Inhibition of the Complement Terminal Pathway.
J Immunol., 197, 2016
5HCC
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TERNARY COMPLEX OF HUMAN COMPLEMENT C5 WITH ORNITHODOROS MOUBATA OMCI AND DERMACENTOR ANDERSONI RACI3.
Descriptor:Complement C5, Complement inhibitor, Dermacentor andersoni RaCI3
Authors:Jore, M.M., Johnson, S., Lea, S.M.
Deposit date:2016-01-04
Release date:2016-03-30
Modification date:2016-05-11
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structural basis for therapeutic inhibition of complement C5.
Nat.Struct.Mol.Biol., 23, 2016
5HCD
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TERNARY COMPLEX OF HUMAN COMPLEMENT C5 WITH ORNITHODOROS MOUBATA OMCI AND RHIPICEPHALUS MICROPLUS RACI2
Descriptor:Complement C5, Complement inhibitor, Rhipicephalus microplus RaCI2
Authors:Jore, M.M., Johnson, S., Lea, S.M.
Deposit date:2016-01-04
Release date:2016-03-30
Modification date:2016-05-11
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Structural basis for therapeutic inhibition of complement C5.
Nat.Struct.Mol.Biol., 23, 2016
5HCE
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TERNARY COMPLEX OF HUMAN COMPLEMENT C5 WITH ORNITHODOROS MOUBATA OMCI AND RHIPICEPHALUS APPENDICULATUS RACI1
Descriptor:Complement C5, Complement inhibitor, Rhipicephalus appendiculatus RaCI1
Authors:Jore, M.M., Johnson, S., Lea, S.M.
Deposit date:2016-01-04
Release date:2016-03-30
Modification date:2016-05-18
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Structural basis for therapeutic inhibition of complement C5.
Nat.Struct.Mol.Biol., 23, 2016
5FO7
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B AT 2.8 ANGSTROM RESOLUTION
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Modification date:2016-06-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FO8
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B IN COMPLEX WITH MCP (CCP1-4)
Descriptor:COMPLEMENT C3 (E.C.3.4.21.47), MEMBRANE COFACTOR PROTEIN
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Modification date:2016-06-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FO9
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B IN COMPLEX WITH CR1 (CCP15- 17)
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, COMPLEMENT RECEPTOR TYPE 1
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Modification date:2016-06-01
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FOA
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B IN COMPLEX WITH DAF (CCP2-4)
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA CHAIN, DECAY ACCELERATING FACTOR, CD55
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Modification date:2016-06-01
Method:X-RAY DIFFRACTION (4.188 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
5FOB
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CRYSTAL STRUCTURE OF HUMAN COMPLEMENT C3B IN COMPLEX WITH SMALLPOX INHIBITOR OF COMPLEMENT (SPICE)
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, SMALLPOX INHIBITOR OF COMPLEMENT SPICE, D15L
Authors:Forneris, F., Wu, J., Xue, X., Gros, P.
Deposit date:2015-11-18
Release date:2016-04-06
Modification date:2016-06-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.
Embo J., 35, 2016
4XAM
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COMPLEMENT COMPONENT C4B
Descriptor:Complement C4b-A
Authors:Mortensen, S., Kidmose, R.T., Petersen, S.V., Szilagyi, A., Andersen, G.R.
Deposit date:2014-12-15
Release date:2015-05-06
Modification date:2015-05-27
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Structural Basis for the Function of Complement Component C4 within the Classical and Lectin Pathways of Complement.
J Immunol., 194, 2015
4FXG
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COMPLEMENT C4 IN COMPLEX WITH MASP-2
Descriptor:Complement C4-A, Mannan-binding lectin serine protease 2 (E.C.3.4.21.104)
Authors:Kidmose, R.T., Laursen, N.S., Andersen, G.R.
Deposit date:2012-07-03
Release date:2012-08-22
Modification date:2012-10-03
Method:X-RAY DIFFRACTION (3.75 Å)
Cite:Structural basis for activation of the complement system by component C4 cleavage.
Proc.Natl.Acad.Sci.USA, 109, 2012
4FXK
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HUMAN COMPLEMENT C4
Descriptor:Complement C4-A
Authors:Kidmose, R.T., Laursen, N.S., Andersen, G.R.
Deposit date:2012-07-03
Release date:2012-08-22
Modification date:2012-10-03
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for activation of the complement system by component C4 cleavage.
Proc.Natl.Acad.Sci.USA, 109, 2012
4E0S
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CRYSTAL STRUCTURE OF C5B-6
Descriptor:Complement C5, Complement component C6
Authors:Aleshin, A.E., Stec, B., DiScipio, R., Liddington, R.C.
Deposit date:2012-03-05
Release date:2012-04-18
Modification date:2012-06-20
Method:X-RAY DIFFRACTION (4.21 Å)
Cite:Crystal structure of c5b-6 suggests structural basis for priming assembly of the membrane attack complex.
J.Biol.Chem., 287, 2012
4ACQ
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ALPHA-2 MACROGLOBULIN
Descriptor:ALPHA-2-MACROGLOBULIN
Authors:Marrero, A., Duquerroy, S., Trapani, S., Goulas, T., Guevara, T., Andersen, G.R., Navaza, J., Sottrup-Jensen, L., Gomis-Ruth, F.X.
Deposit date:2011-12-17
Release date:2012-02-22
Modification date:2014-12-17
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:The Crystal Structure of Human Alpha(2)-Macroglobulin Reveals a Unique Molecular Cage.
Angew.Chem.Int.Ed.Engl., 51, 2012
4A5W
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CRYSTAL STRUCTURE OF C5B6
Descriptor:COMPLEMENT C5, COMPLEMENT COMPONENT C6
Authors:Hadders, M.A., Bubeck, D., Forneris, F., Pangburn, M., Llorca, O., Lea, S.M., Gros, P.
Deposit date:2011-10-28
Release date:2012-03-14
Modification date:2012-10-31
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5B6 and Sc5B9.
Cell Rep., 1, 2012
3T4A
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STRUCTURE OF A TRUNCATED FORM OF STAPHYLOCOCCAL COMPLEMENT INHIBITOR B BOUND TO HUMAN C3C AT 3.4 ANGSTROM RESOLUTION
Descriptor:Complement C3 beta chain, Complement C3c alpha' chain fragment 1, Complement C3c alpha' chain fragment 2, Fibrinogen-binding protein
Authors:Garcia, B.L., Geisbrecht, B.V., Summers, B.J.
Deposit date:2011-07-25
Release date:2011-11-23
Modification date:2013-05-22
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Diversity in the C3b Convertase Contact Residues and Tertiary Structures of the Staphylococcal Complement Inhibitor (SCIN) Protein Family.
J.Biol.Chem., 287, 2012
3PVM
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STRUCTURE OF COMPLEMENT C5 IN COMPLEX WITH CVF
Descriptor:Complement C5, Cobra venom factor
Authors:Laursen, N.S., Andersen, K.R., Braren, I., Sottrup-Jensen, L., Spillner, E., Andersen, G.R.
Deposit date:2010-12-07
Release date:2011-01-19
Modification date:2014-01-22
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.
Embo J., 30, 2011
3PRX
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STRUCTURE OF COMPLEMENT C5 IN COMPLEX WITH CVF AND SSL7
Descriptor:Complement C5, Cobra venom factor, Superantigen-like protein 7
Authors:Laursen, N.S., Andersen, G.R., Sottrup-Jensen, L., Andersen, K.R., Spillner, E., Braren, I.
Deposit date:2010-11-30
Release date:2011-01-19
Modification date:2011-04-13
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.
Embo J., 30, 2011
2XWJ
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CRYSTAL STRUCTURE OF COMPLEMENT C3B IN COMPLEX WITH FACTOR B
Descriptor:COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3 ALPHA CHAIN, COMPLEMENT FACTOR B
Authors:Forneris, F., Ricklin, D., Wu, J., Tzekou, A., Wallace, R.S., Lambris, J.D., Gros, P.
Deposit date:2010-11-04
Release date:2011-01-12
Modification date:2012-04-11
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation.
Science, 330, 2010
2XWB
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CRYSTAL STRUCTURE OF COMPLEMENT C3B IN COMPLEX WITH FACTORS B AND D
Descriptor:COMPLEMENT C3B BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, COMPLEMENT FACTOR B (E.C.3.4.21.47), COMPLEMENT FACTOR D (E.C.3.4.21.46)
Authors:Forneris, F., Ricklin, D., Wu, J., Tzekou, A., Wallace, R.S., Lambris, J.D., Gros, P.
Deposit date:2010-11-01
Release date:2011-01-12
Modification date:2012-04-11
Method:X-RAY DIFFRACTION (3.49 Å)
Cite:Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation.
Science, 330, 2010
3OHX
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MOLECULAR BASIS FOR COMPLEMENT RECOGNITION AND INHIBITION DETERMINED BY CRYSTALLOGRAPHIC STUDIES OF THE STAPHYLOCOCCAL COMPLEMENT INHIBITOR (SCIN) BOUND TO C3C AND C3B
Descriptor:Complement C3, Staphylococcal complement inhibitor
Authors:Geisbrecht, B.V., Garcia, B.L.
Deposit date:2010-08-18
Release date:2010-09-01
Modification date:2013-04-24
Method:X-RAY DIFFRACTION (3.503 Å)
Cite:Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.
J.Mol.Biol., 402, 2010
3NMS
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STAPHYLOCOCCAL COMPLEMENT INHIBITOR (SCIN) IN COMPLEX WITH HUMAN COMPLEMENT C3C
Descriptor:Complement C3, Staphylococcal complement inhibitor
Authors:Geisbrecht, B.V., Garcia, B.L.
Deposit date:2010-06-22
Release date:2010-08-04
Modification date:2010-09-15
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.
J.Mol.Biol., 402, 2010
3L5N
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STAPHYLOCOCCAL COMPLEMENT INHIBITOR (SCIN) IN COMPLEX WITH HUMAN COMPLEMENT COMPONENT C3B
Descriptor:Complement C3, Staphylococcal complement inhibitor
Authors:Geisbrecht, B.V., Garcia, B.L.
Deposit date:2009-12-22
Release date:2010-08-04
Modification date:2010-09-15
Method:X-RAY DIFFRACTION (7.536 Å)
Cite:Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.
J.Mol.Biol., 402, 2010
3L3O
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STAPHYLOCOCCAL COMPLEMENT INHIBITOR (SCIN) IN COMPLEX WITH HUMAN COMPLEMENT COMPONENT C3C
Descriptor:Complement C3, Staphylococcal complement inhibitor
Authors:Geisbrecht, B.V., Garcia, B.G.
Deposit date:2009-12-17
Release date:2010-08-04
Modification date:2010-09-15
Method:X-RAY DIFFRACTION (3.405 Å)
Cite:Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b.
J.Mol.Biol., 402, 2010
3KM9
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STRUCTURE OF COMPLEMENT C5 IN COMPLEX WITH THE C-TERMINAL BETA-GRASP DOMAIN OF SSL7
Descriptor:Complement C5, Staphylococcal enterotoxin-like toxin
Authors:Laursen, N.S., Gordon, N., Hermans, S., Lorenz, N., Jackson, N., Wines, B., Spillner, E., Christensen, J.B., Jensen, M., Fredslund, F., Bjerre, M., Sottrup-Jensen, L., Fraser, J.D., Andersen, G.R.
Deposit date:2009-11-10
Release date:2009-12-01
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
Proc.Natl.Acad.Sci.USA, 107, 2010
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