7Q1Y

X-ray structure of human A2ML1

Summary for 7Q1Y

• Entry DOI: 10.2210/pdb7q1y/pdb
• Descriptor: Alpha-2-macroglobulin-like protein 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: protease inhibitor, thioester protein, a2m family, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 323344.91

Authors

Andersen, G.R.,Zarantonello, A.,Enghild, J.J.,Nielsen, N.S. (deposition date: 2021-10-22, release date: 2022-04-20, Last modification date: 2022-11-02)

• Primary citation: Nielsen, N.S.,Zarantonello, A.,Harwood, S.L.,Jensen, K.T.,Kjoge, K.,Thogersen, I.B.,Schauser, L.,Karlsen, J.L.,Andersen, G.R.,Enghild, J.J.; Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.; Nat Commun, 13:3033-3033, 2022; PubMed: 35641520; DOI: 10.1038/s41467-022-30758-x

Experimental method

X-RAY DIFFRACTION (4.4 Å)