8ENU

Structure of the C3bB proconvertase in complex with lufaxin

Summary for 8ENU

Entry DOI	10.2210/pdb8enu/pdb
EMDB information	28279
Descriptor	Complement C3 beta chain, Complement C3b alpha' chain, Complement factor B, ... (7 entities in total)
Functional Keywords	complement, alternative pathway, inhibitor, sand fly, immune system
Biological source	Lutzomyia longipalpis More
Total number of polymer chains	4
Total formula weight	296148.26
Authors	Andersen, J.F.,Lei, H. (deposition date: 2022-09-30, release date: 2023-08-09, Last modification date: 2024-02-21)
Primary citation	Andersen, J.F.,Lei, H.,Strayer, E.C.,Kanai, T.,Pham, V.,Pan, X.Z.,Alvarenga, P.H.,Gerber, G.F.,Asojo, O.A.,Francischetti, I.M.B.,Brodsky, R.A.,Valenzuela, J.G.,Ribeiro, J.M.C. A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism. Blood, 141:3109-3121, 2023 Cited by PubMed: 36947859 DOI: 10.1182/blood.2022019359 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.22 Å)

Structure validation