7Q62

Structure of TEV cleaved A2ML1 dimer (A2ML1-TT dimer)

Summary for 7Q62

• Entry DOI: 10.2210/pdb7q62/pdb
• EMDB information: 13850
• Descriptor: Alpha-2-macroglobulin-like protein 1, 2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total)
• Functional Keywords: protease inhibitor, thioester, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 320890.64

Authors

Nielsen, N.S.,Zarantonello, A.,Andersen, G.R. (deposition date: 2021-11-05, release date: 2022-04-20, Last modification date: 2022-11-02)

• Primary citation: Nielsen, N.S.,Zarantonello, A.,Harwood, S.L.,Jensen, K.T.,Kjoge, K.,Thogersen, I.B.,Schauser, L.,Karlsen, J.L.,Andersen, G.R.,Enghild, J.J.; Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.; Nat Commun, 13:3033-3033, 2022; PubMed: 35641520; DOI: 10.1038/s41467-022-30758-x

Experimental method

ELECTRON MICROSCOPY (3.18 Å)