3B64
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MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) FROM /LEISHMANIA MAJOR
Descriptor:Macrophage migration inhibitory factor-like protein
Authors:Zierow, S., Cho, Y., Lolis, E.
Deposit date:2007-10-27
Release date:2008-06-10
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.03 Å)
Cite:A leishmania ortholog of macrophage migration inhibitory factor modulates host macrophage responses.
J.Immunol., 180, 2008
3KAN
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D-DOPACHROME TAUTOMERASE (D-DT)/MACROPHAGE MIGRATION INHIBITORY FACTOR 2 (MIF2) COMPLEXED WITH INHIBITOR 4-IPP
Descriptor:D-dopachrome tautomerase
Authors:Zierow, S., Lolis, E.
Deposit date:2009-10-19
Release date:2011-04-20
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Crystal Structure of D-DOPACHROME TAUTOMERASE (D-DT)/MACROPHAGE MIGRATION INHIBITORY FACTOR 2 (MIF2) COMPLEXED WITH INHIBITOR 4-IPP
To be Published
3DJH
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MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) AT 1.25 A RESOLUTION
Descriptor:Macrophage migration inhibitory factor (E.C.5.3.2.1)
Authors:Crichlow, G.V., Lolis, E.
Deposit date:2008-06-23
Release date:2008-12-23
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions.
Biochemistry, 48, 2009
3IJJ
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TERNARY COMPLEX OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) BOUND BOTH TO 4-HYDROXYPHENYLPYRUVATE AND TO THE ALLOSTERIC INHIBITOR AV1013 (R-STEREOISOMER)
Descriptor:Macrophage migration inhibitory factor (E.C.5.3.2.1, 5.3.3.12)
Authors:Crichlow, G.V., Cho, Y., Lolis, E.J.
Deposit date:2009-08-04
Release date:2010-06-16
Modification date:2010-06-30
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast.
Proc.Natl.Acad.Sci.USA, 107, 2010
4GRN
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CRYSTAL STRUCTURE OF PAAM MUTANT OF HUMAN MIF
Descriptor:Macrophage migration inhibitory factor (E.C.5.3.2.1, 5.3.3.12)
Authors:Fan, C., Lolis, E., Rajesekaran, D.
Deposit date:2012-08-26
Release date:2013-09-25
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:crystallographic and biological chacerterization of N- and C-terminus of MIF
To be Published
4GRP
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CRYSTALLOGRAPHIC AND BIOLOGICAL CHARACTERIZATION OF N- AND C- TERMINUS MUTANTS OF HUMAN MIF
Descriptor:Macrophage migration inhibitory factor (E.C.5.3.2.1, 5.3.3.12)
Authors:Fan, C., Lolis, E.
Deposit date:2012-08-26
Release date:2013-10-02
Modification date:2014-04-02
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:Crystallographic and biological characterization of N- and C- terminus mutants of human MIF
To be Published
2GDG
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CRYSTAL STRUCTURE OF COVALENTLY MODIFIED MACROPHAGE INHIBITORY FACTOR
Descriptor:Macrophage migration inhibitory factor (E.C.5.3.2.1)
Authors:Golubkov, P.A., Hackert, M.L.
Deposit date:2006-03-16
Release date:2006-07-04
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Inactivation of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor by 2-oxo-4-phenyl-3-butynoate.
Bioorg.Chem., 34, 2006
4GRR
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CHARACTERIZATION OF N- AND C- TERMINUS MUTANTS OF HUMAN MIF
Descriptor:Macrophage migration inhibitory factor (E.C.5.3.2.1, 5.3.3.12)
Authors:Fan, C., Lolis, E.
Deposit date:2012-08-26
Release date:2013-09-25
Modification date:2014-04-02
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Characterization of N- and C- terminus mutants of human MIF
To be Published
1GD0
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HUMAN MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)
Descriptor:HUMAN MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)
Authors:Kurihara, H., Katayama, N.
Deposit date:2000-08-24
Release date:2001-02-21
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography.
J.Med.Chem., 44, 2001
4F2K
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MACROPHAGE MIGRATION INHIBITORY FACTOR COVALENTLY COMPLEXED WITH PHENETHYLISOTHIOCYANATE
Descriptor:Macrophage migration inhibitory factor (E.C.5.3.2.1, 5.3.3.12)
Authors:Tyndall, J.D.A., Bernhagen, J., Hampton, M.B., Wilbanks, S.M., Rutledge, M.T.
Deposit date:2012-05-08
Release date:2012-06-06
Modification date:2012-12-26
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate
Acta Crystallogr.,Sect.F, 68, 2012
1DPT
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D-DOPACHROME TAUTOMERASE
Descriptor:D-DOPACHROME TAUTOMERASE
Authors:Sugimoto, H., Taniguchi, M., Nakagawa, A., Tanaka, I.
Deposit date:1998-05-11
Release date:1999-03-30
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution.
Biochemistry, 38, 1999
3CE4
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STRUCTURE OF MACROPHAGE MIGRATION INHIBITORY FACTOR COVALENTLY INHIBITED BY PMSF TREATMENT
Descriptor:Macrophage migration inhibitory factor
Authors:Crichlow, G.V., Lolis, E.
Deposit date:2008-02-28
Release date:2008-12-30
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions.
Biochemistry, 48, 2009
4K9G
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1.55 A CRYSTAL STRUCTURE OF MACROPHAGE MIGRATION INHIBITORY FACTOR BOUND TO ISO-66 AND A RELATED COMPOUND
Descriptor:Macrophage migration inhibitory factor (E.C.5.3.2.1, 5.3.3.12)
Authors:Crichlow, G.V., Al-Abed, Y., Lolis, E.J.
Deposit date:2013-04-19
Release date:2014-09-24
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:ISO-66, a novel inhibitor of macrophage migration, shows efficacy in melanoma and colon cancer models.
INT J ONCOL., 45, 2014
3JSG
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CRYSTAL STRUCTURE OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH HYDROXYQUINOLINE INHIBITOR 707 AT 1.58A RESOLUTION
Descriptor:Macrophage migration inhibitory factor (E.C.5.3.2.1, 5.3.3.12)
Authors:Mclean, L., Zhang, Y.
Deposit date:2009-09-10
Release date:2009-11-10
Modification date:2010-04-28
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening.
Bioorg.Med.Chem.Lett., 19, 2009
3SMB
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PHENETHYLISOTHIOCYANATE COVALENTLY BOUND TO MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)
Descriptor:Macrophage migration inhibitory factor (E.C.5.3.2.1, 5.3.3.12)
Authors:Crichlow, G.V., Lolis, E.J.
Deposit date:2011-06-27
Release date:2012-10-03
Modification date:2013-02-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural interactions dictate the kinetics of macrophage migration inhibitory factor inhibition by different cancer-preventive isothiocyanates.
Biochemistry, 51, 2012
4ETG
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CRYSTAL STRUCTURE OF MIF L46G MUTANT
Descriptor:Macrophage migration inhibitory factor (E.C.5.3.2.1, 5.3.3.12)
Authors:Ashrafi, A., Pojer, F., Lashuel, H.
Deposit date:2012-04-24
Release date:2012-10-03
Modification date:2013-08-07
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Characterization of molecular determinants of the conformational stability of macrophage migration inhibitory factor: leucine 46 hydrophobic pocket.
Plos One, 7, 2012
4OSF
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4-(2-ISOTHIOCYANATOETHYL)PHENOL INHIBITOR COMPLEXED WITH MACROPHAGE MIGRATION INHIBITORY FACTOR
Descriptor:Macrophage migration inhibitory factor (E.C.5.3.2.1, 5.3.3.12)
Authors:Spencer, E.S., Dale, E.J., Gommans, A.L., Vo, C.T., Rutledge, M.T., Nakatani, Y., Gamble, A.B., Smith, R.A.J., Wilbanks, S.M., Hampton, M.B., Tyndall, J.D.A.
Deposit date:2014-02-12
Release date:2014-03-12
Modification date:2015-04-01
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor
Eur.J.Med.Chem., 93, 2015
4PLU
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CRYSTAL STRUCTURE OF MACROPHAGE MIGRATION INHIBITORY FACTOR IN COMPLEX WITH BENZALDEHYDE
Descriptor:Macrophage Migration Inhibitory Factor
Authors:Pantouris, G., Lolis, E.
Deposit date:2014-05-19
Release date:2015-09-30
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:An Analysis of MIF Structural Features that Control Functional Activation of CD74.
Chem.Biol., 22, 2015
4TRF
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CRYSTAL STRUCTURE OF MACROPHAGE MIGRATION INHIBITORY FACTOR IN COMPLEX WITH N-(PYRIDIN-3-YLMETHYL)THIOFORMAMIDE
Descriptor:Macrophage migration inhibitory factor
Authors:Pantouris, G., Lolis, E.
Deposit date:2014-06-16
Release date:2015-09-30
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:An Analysis of MIF Structural Features that Control Functional Activation of CD74.
Chem.Biol., 22, 2015
2XCZ
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CRYSTAL STRUCTURE OF MACROPHAGE MIGRATION INHIBITORY FACTOR HOMOLOGUE FROM PROCHLOROCOCCUS MARINUS
Descriptor:POSSIBLE ATLS1-LIKE LIGHT-INDUCIBLE PROTEIN
Authors:Wasiel, A.A., Rozeboom, H.J., Hauke, D., Baas, B.J., Zandvoort, E., Quax, W.J., Thunnissen, A.M.W.H., Poelarends, G.J.
Deposit date:2010-04-27
Release date:2010-09-01
Modification date:2011-07-06
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Structural and Functional Characterization of a Macrophage Migration Inhibitory Factor Homologue from the Marine Cyanobacterium Prochlorococcus Marinus.
Biochemistry, 49, 2010
4GRQ
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CHARACTERIZATION OF N- AND C- TERMINUS MUTANTS OF HUMAN MIF
Descriptor:Macrophage migration inhibitory factor (E.C.5.3.2.1, 5.3.3.12)
Authors:Fan, C., Lolis, E.
Deposit date:2012-08-26
Release date:2013-10-02
Modification date:2014-04-02
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Characterization of N- and C- terminus mutants of human MIF
To be Published
3WNS
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ALLYL ISOTHIOCYANATE INHIBITOR COMPLEXED WITH MACROPHAGE MIGRATION INHIBITORY FACTOR
Descriptor:Macrophage migration inhibitory factor (E.C.5.3.2.1, 5.3.3.12)
Authors:Spencer, E.S., Dale, E.J., Gommans, A.L., Rutledge, M.T., Gamble, A.B., Smith, R.A.J., Wilbanks, S.M., Hampton, M.B., Tyndall, J.D.A.
Deposit date:2013-12-16
Release date:2014-03-05
Modification date:2015-04-01
Method:X-RAY DIFFRACTION (1.658 Å)
Cite:Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor
Eur.J.Med.Chem., 93, 2015
3IJG
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MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) BOUND TO THE (R)-STEREOISOMER OF AV1013
Descriptor:Macrophage migration inhibitory factor (E.C.5.3.2.1, 5.3.3.12)
Authors:Crichlow, G.V., Cho, Y., Lolis, E.J.
Deposit date:2009-08-04
Release date:2010-06-16
Modification date:2010-06-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast.
Proc.Natl.Acad.Sci.USA, 107, 2010
3L5V
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CRYSTAL STRUCTURE OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH GLYCEROL AT 1.70A RESOLUTION
Descriptor:Macrophage migration inhibitory factor (E.C.5.3.2.1, 5.3.3.12)
Authors:McLean, L., Zhang, Y.
Deposit date:2009-12-22
Release date:2010-03-09
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site.
Bioorg.Med.Chem.Lett., 20, 2010
4EUI
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CRYSTAL STRUCTURE OF MIF L46F MUTANT
Descriptor:Macrophage migration inhibitory factor (E.C.5.3.2.1, 5.3.3.12)
Authors:Ashrafi, A., Pojer, F., Lashuel, H.
Deposit date:2012-04-25
Release date:2012-10-03
Modification date:2013-07-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Characterization of molecular determinants of the conformational stability of macrophage migration inhibitory factor: leucine 46 hydrophobic pocket.
Plos One, 7, 2012
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