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3B64
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BU of 3b64 by Molmil
Macrophage Migration Inhibitory Factor (MIF) From /Leishmania Major
Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor-like protein
Authors:Zierow, S, Cho, Y, Lolis, E.
Deposit date:2007-10-27
Release date:2008-06-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.03 Å)
Cite:A leishmania ortholog of macrophage migration inhibitory factor modulates host macrophage responses.
J.Immunol., 180, 2008
9BNQ
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N-(4-(isothiocyanatomethyl)phenyl)methanesulfonamide complexed with Macrophage Migration Inhibitory Factor
Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, N-{[4-(methanesulfonamido)phenyl]methyl}methanethioamide, ...
Authors:Fellner, M, Rutledge, M.T, Putha, L, Kok, L.K, Gamble, A.B, Wilbanks, S.M, Vernall, A.J, Tyndall, J.D.A.
Deposit date:2024-05-02
Release date:2024-07-24
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Covalent isothiocyanate inhibitors of macrophage migration inhibitory factor as potential colorectal cancer treatments.
Chemmedchem, 2024
7MW7
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Crystal structure of P1G mutant of D-dopachrome tautomerase
Descriptor: D-dopachrome decarboxylase, SODIUM ION, SULFATE ION
Authors:Manjula, R, Murphy, E.L, Murphy, J.W, Lolis, E.
Deposit date:2021-05-15
Release date:2021-08-18
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J.Biol.Chem., 297, 2021
3KAN
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BU of 3kan by Molmil
D-dopachrome tautomerase (D-DT)/macrophage migration inhibitory factor 2 (MIF2) complexed with inhibitor 4-IPP
Descriptor: 4-phenylpyrimidine, CHLORIDE ION, D-dopachrome tautomerase
Authors:Zierow, S, Lolis, E.
Deposit date:2009-10-19
Release date:2011-04-20
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment.
Faseb J., 28, 2014
6B1K
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Macrophage Migration Inhibitory Factor in Complex with a Naphthyridinone Inhibitor (3a)
Descriptor: 2-[1-(4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]-7-methyl-1,7-naphthyridin-8(7H)-one, GLYCEROL, Macrophage migration inhibitory factor, ...
Authors:Krimmer, S.G, Robertson, M.J, Jorgensen, W.L.
Deposit date:2017-09-18
Release date:2018-01-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:Adding a Hydrogen Bond May Not Help: Naphthyridinone vs Quinoline Inhibitors of Macrophage Migration Inhibitory Factor.
ACS Med Chem Lett, 8, 2017
8VFL
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Crystal Structure of WT D-Dopachrome Tautomerase (D-DT) at 290K
Descriptor: D-dopachrome decarboxylase
Authors:Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G.
Deposit date:2023-12-21
Release date:2024-05-01
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes.
J.Med.Chem., 67, 2024
8VG7
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Crystal Structure of T115A Variant of D-Dopachrome Tautomerase (D-DT)
Descriptor: D-dopachrome decarboxylase
Authors:Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G.
Deposit date:2023-12-23
Release date:2024-05-01
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes.
J.Med.Chem., 67, 2024
3IJJ
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Ternary Complex of Macrophage Migration Inhibitory Factor (MIF) Bound Both to 4-hydroxyphenylpyruvate and to the Allosteric Inhibitor AV1013 (R-stereoisomer)
Descriptor: (2E)-2-hydroxy-3-(4-hydroxyphenyl)prop-2-enoic acid, (2R)-2-amino-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one, 3-(4-HYDROXY-PHENYL)PYRUVIC ACID, ...
Authors:Crichlow, G.V, Cho, Y, Lolis, E.J.
Deposit date:2009-08-04
Release date:2010-06-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast.
Proc.Natl.Acad.Sci.USA, 107, 2010
4GRN
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crystal structure of PAAM mutant of human MIF
Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor, SODIUM ION, ...
Authors:Fan, C, Lolis, E, Rajesekaran, D.
Deposit date:2012-08-26
Release date:2013-09-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:crystallographic and biological chacerterization of N- and C-terminus of MIF
To be Published
3DJH
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Macrophage Migration Inhibitory Factor (MIF) at 1.25 A Resolution
Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
Authors:Crichlow, G.V, Lolis, E.
Deposit date:2008-06-23
Release date:2008-12-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions.
Biochemistry, 48, 2009
7MSE
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High-resolution crystal structure of hMIF2 with tartrate at the active site
Descriptor: D-dopachrome decarboxylase, L(+)-TARTARIC ACID
Authors:Murphy, E.L, Manjula, R, Murphy, J.W, Lolis, E.
Deposit date:2021-05-11
Release date:2021-08-18
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J.Biol.Chem., 297, 2021
4GRP
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Crystallographic and biological characterization of N- and C- terminus mutants of human MIF
Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor, SULFATE ION
Authors:Fan, C, Lolis, E.
Deposit date:2012-08-26
Release date:2013-10-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:Crystallographic and biological characterization of N- and C- terminus mutants of human MIF
To be Published
7XTX
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BU of 7xtx by Molmil
High resolution crystal structure of human macrophage migration inhibitory factor in complex with methotrexate
Descriptor: 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
Authors:Sugishima, K, Noguchi, K, Yohda, M, Odaka, M, Matsumura, H.
Deposit date:2022-05-18
Release date:2023-05-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Identification of methotrexate as an inhibitor of macrophage migration inhibitory factor by high-resolution crystal structure analysis
To Be Published
8VFN
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Crystal Structure of WT D-Dopachrome Tautomerase (D-DT) at 310K
Descriptor: D-dopachrome decarboxylase
Authors:Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G.
Deposit date:2023-12-21
Release date:2024-05-01
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes.
J.Med.Chem., 67, 2024
8DBB
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BU of 8dbb by Molmil
Crystal structure of DDT with the selective inhibitor 2,5-Pyridinedicarboxylic Acid
Descriptor: CITRIC ACID, D-dopachrome decarboxylase, pyridine-2,5-dicarboxylic acid
Authors:Parkins, A, Banumathi, S, Pantouris, G.
Deposit date:2022-06-14
Release date:2023-03-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:2,5-Pyridinedicarboxylic acid is a bioactive and highly selective inhibitor of D-dopachrome tautomerase.
Structure, 31, 2023
8IMR
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BU of 8imr by Molmil
Structure of ligand-free human macrophage migration inhibitory factor
Descriptor: 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
Authors:Sugishima, K, Noguchi, K, Yohda, M, Odaka, M, Matsumura, H.
Deposit date:2023-03-07
Release date:2024-03-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Identification of methotrexate as an inhibitor of macrophage migration inhibitory factor by high-resolution crystal structure analysis
To Be Published
8VFW
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Crystal Structure of V113N D-Dopachrome Tautomerase (D-DT)
Descriptor: CITRIC ACID, D-dopachrome decarboxylase
Authors:Parkins, A, Wolff, A, Thompson, M.C, Pantouris, G.
Deposit date:2023-12-22
Release date:2024-05-01
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes.
J.Med.Chem., 67, 2024
7MRU
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BU of 7mru by Molmil
Crystal structure of S62A MIF2 mutant
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, D-dopachrome decarboxylase
Authors:Murphy, E.L, Manjula, R, Murphy, J.W, Lolis, E.
Deposit date:2021-05-09
Release date:2021-08-18
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J.Biol.Chem., 297, 2021
8VG8
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BU of 8vg8 by Molmil
Crystal Structure of T115A Variant of D-Dopachrome Tautomerase (D-DT) Bound to 4CPPC
Descriptor: 4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid, D-dopachrome decarboxylase
Authors:Parkins, A, Pilien, A, Wolff, A, Thompson, M.C, Pantouris, G.
Deposit date:2023-12-23
Release date:2024-05-01
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes.
J.Med.Chem., 67, 2024
8VFO
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Crystal Structure of L117G Variant of D-Dopachrome Tautomerase (D-DT)
Descriptor: CITRIC ACID, D-dopachrome decarboxylase
Authors:Parkins, A, Pilien, A, Thompson, M.C, Pantouris, G.
Deposit date:2023-12-21
Release date:2024-05-01
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:The C-terminal Region of D-DT Regulates Molecular Recognition for Protein-Ligand Complexes.
J.Med.Chem., 67, 2024
5B4O
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Crystal structure of Macrophage Migration Inhibitory Factor in complex with BTZO-14
Descriptor: 1,2-ETHANEDIOL, 2-pyridin-3-yl-1,3-benzothiazin-4-one, Macrophage migration inhibitory factor, ...
Authors:Oki, H, Igaki, S, Moriya, Y, Hayano, Y, Habuka, N.
Deposit date:2016-04-07
Release date:2016-04-20
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitory factor regulates ARE-mediated gene expression
Chem. Biol., 17, 2010
7E47
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Crystal structure of compound 6 bound to MIF
Descriptor: (2S,3R,4R,5R,6R)-2-[(2S,3R,4S,5R,6S)-6-(hydroxymethyl)-2-[[(2R,4R)-2-(4-hydroxyphenyl)-4,5-bis(oxidanyl)-3,4-dihydro-2H-chromen-7-yl]oxy]-4,5-bis(oxidanyl)oxan-3-yl]oxy-6-methyl-oxane-3,4,5-triol, CHLORIDE ION, Macrophage migration inhibitory factor
Authors:Fan, C.P, Yang, L, Guo, D.Y.
Deposit date:2021-02-10
Release date:2023-02-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors.
J.Agric.Food Chem., 69, 2021
6FVH
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Macrophage Migration Inhibitory Factor (MIF) with Covalently Bound PITC
Descriptor: Macrophage migration inhibitory factor, N-phenylthioformamide, SULFATE ION
Authors:Samygina, V.R, Bourenkov, G, Sokolov, A.V.
Deposit date:2018-03-02
Release date:2018-06-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural Study of the Complex Formed by Ceruloplasmin and Macrophage Migration Inhibitory Factor.
Biochemistry Mosc., 83, 2018
8AP3
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BU of 8ap3 by Molmil
Structure of A. thaliana MIF/D-DT-like protein-2 (MDL2)
Descriptor: MIF homologue
Authors:Manjula, R, Basquin, J, Lolis, E.
Deposit date:2022-08-09
Release date:2023-08-23
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure of A. thaliana MIF/D-DT-like protein-2 (MDL2)
To Be Published
6C5F
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Human D-Dopachrome tautomerase (D-DT)/ macrophage migration inhibitory factor 2 (MIF2) complexed with the selective inhibitor 4-CPPC
Descriptor: 4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid, D-dopachrome decarboxylase
Authors:Pantouris, G, Lolis, E.J.
Deposit date:2018-01-16
Release date:2018-06-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural Plasticity in the C-Terminal Region of Macrophage Migration Inhibitory Factor-2 Is Associated with an Induced Fit Mechanism for a Selective Inhibitor.
Biochemistry, 57, 2018

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PDB entries from 2024-09-18

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