7E47

Crystal structure of compound 6 bound to MIF

Summary for 7E47

• Entry DOI: 10.2210/pdb7e47/pdb
• Descriptor: Macrophage migration inhibitory factor, CHLORIDE ION, (2S,3R,4R,5R,6R)-2-[(2S,3R,4S,5R,6S)-6-(hydroxymethyl)-2-[[(2R,4R)-2-(4-hydroxyphenyl)-4,5-bis(oxidanyl)-3,4-dihydro-2H-chromen-7-yl]oxy]-4,5-bis(oxidanyl)oxan-3-yl]oxy-6-methyl-oxane-3,4,5-triol, ... (4 entities in total)
• Functional Keywords: tautomerase and cytokine, isomerase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 3
• Total formula weight: 37895.89

Authors

Fan, C.P.,Yang, L.,Guo, D.Y. (deposition date: 2021-02-10, release date: 2023-02-15, Last modification date: 2023-11-29)

• Primary citation: Yang, L.,Guo, D.,Fan, C.; Identification and Structure-Activity Relationships of Dietary Flavonoids as Human Macrophage Migration Inhibitory Factor (MIF) Inhibitors.; J.Agric.Food Chem., 69:10138-10150, 2021; PubMed: 34459191; DOI: 10.1021/acs.jafc.1c03367

Experimental method

X-RAY DIFFRACTION (1.38 Å)