3IJJ
Ternary Complex of Macrophage Migration Inhibitory Factor (MIF) Bound Both to 4-hydroxyphenylpyruvate and to the Allosteric Inhibitor AV1013 (R-stereoisomer)
Summary for 3IJJ
Entry DOI | 10.2210/pdb3ijj/pdb |
Related | 1CA7 3IJG |
Descriptor | Macrophage migration inhibitory factor, (2E)-2-hydroxy-3-(4-hydroxyphenyl)prop-2-enoic acid, 3-(4-HYDROXY-PHENYL)PYRUVIC ACID, ... (6 entities in total) |
Functional Keywords | allosteric inhibition, cytokine, immune response, inflammatory response, innate immunity, isomerase, phosphoprotein, secreted |
Biological source | Homo sapiens (human) |
Cellular location | Secreted : P14174 |
Total number of polymer chains | 3 |
Total formula weight | 38661.03 |
Authors | Crichlow, G.V.,Cho, Y.,Lolis, E.J. (deposition date: 2009-08-04, release date: 2010-06-16, Last modification date: 2023-09-06) |
Primary citation | Cho, Y.,Crichlow, G.V.,Vermeire, J.J.,Leng, L.,Du, X.,Hodsdon, M.E.,Bucala, R.,Cappello, M.,Gross, M.,Gaeta, F.,Johnson, K.,Lolis, E.J. Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc.Natl.Acad.Sci.USA, 107:11313-11318, 2010 Cited by PubMed: 20534506DOI: 10.1073/pnas.1002716107 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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