3IJG

Macrophage Migration Inhibitory Factor (MIF) Bound to the (R)-Stereoisomer of AV1013

Summary for 3IJG

• Entry DOI: 10.2210/pdb3ijg/pdb
• Related: 3IJJ
• Descriptor: Macrophage migration inhibitory factor, CHLORIDE ION, (2R)-2-amino-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one, ... (4 entities in total)
• Functional Keywords: allosteric binding, cytokine, immune response, inflammatory response, innate immunity, isomerase, phosphoprotein, secreted
• Biological source: Homo sapiens (human)
• Cellular location: Secreted : P14174
• Total number of polymer chains: 3
• Total formula weight: 37650.99

Authors

Crichlow, G.V.,Cho, Y.,Lolis, E.J. (deposition date: 2009-08-04, release date: 2010-06-16, Last modification date: 2023-09-06)

• Primary citation: Cho, Y.,Crichlow, G.V.,Vermeire, J.J.,Leng, L.,Du, X.,Hodsdon, M.E.,Bucala, R.,Cappello, M.,Gross, M.,Gaeta, F.,Johnson, K.,Lolis, E.J.; Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast.; Proc.Natl.Acad.Sci.USA, 107:11313-11318, 2010; PubMed: 20534506; DOI: 10.1073/pnas.1002716107

Experimental method

X-RAY DIFFRACTION (1.7 Å)