5B4O

Crystal structure of Macrophage Migration Inhibitory Factor in complex with BTZO-14

Summary for 5B4O

Entry DOI	10.2210/pdb5b4o/pdb
Descriptor	Macrophage migration inhibitory factor, 2-pyridin-3-yl-1,3-benzothiazin-4-one, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	isomerase
Biological source	Homo sapiens (Human)
Cellular location	Secreted : P14174
Total number of polymer chains	3
Total formula weight	38952.92
Authors	Oki, H.,Igaki, S.,Moriya, Y.,Hayano, Y.,Habuka, N. (deposition date: 2016-04-07, release date: 2016-04-20, Last modification date: 2023-11-08)
Primary citation	Kimura, H.,Sato, Y.,Tajima, Y.,Suzuki, H.,Yukitake, H.,Imaeda, T.,Kajino, M.,Oki, H.,Takizawa, M.,Tanida, S. BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitory factor regulates ARE-mediated gene expression Chem. Biol., 17:1282-1294, 2010 Cited by PubMed: 21168764 DOI: 10.1016/j.chembiol.2010.10.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.37 Å)

Structure validation