4ZS7
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STRUCTURAL MIMICRY OF RECEPTOR INTERACTION BY ANTAGONISTIC IL-6 ANTIBODIES
Descriptor:Interleukin-6, Llama Fab fragment 68F2 heavy chain, Llama Fab fragment 68F2 light chain
Authors:Blanchetot, C., De Jonge, N., Desmyter, A., Ongenae, N., Hofman, E., Klarenbeek, A., Sadi, A., Hultberg, A., Kretz-Rommel, A., Spinelli, S., Loris, R., Cambillau, C., de Haard, H.
Deposit date:2015-05-13
Release date:2016-05-04
Modification date:2016-07-06
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies.
J.Biol.Chem., 291, 2016
4O9H
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STRUCTURE OF INTERLEUKIN-6 IN COMPLEX WITH A CAMELID FAB FRAGMENT
Descriptor:Interleukin-6, Heavy Chain of the Camelid Fab fragment 61H7, Light Chain of the Camelid Fab fragment 61H7
Authors:Klarenbeek, A., Blanchetot, C., Schragel, G., Sadi, A.S., Ongenae, N., Hemrika, W., Wijdenes, J., Spinelli, S., Desmyter, A., Cambillau, C., Hultberg, A., Kretz-rommel, A., Dreier, T., De haard, H.J.W., Roovers, R.C.
Deposit date:2014-01-02
Release date:2015-04-15
Modification date:2015-04-29
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Combining residues of naturally-occurring Camelid somatic affinity variants yields ultra-potent human therapeutic IL-6 antibodies
To be Published
4NI9
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CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN 6 IN COMPLEX WITH A MODIFIED NUCLEOTIDE APTAMER (SOMAMER SL1025), FORM 2
Descriptor:PROTEIN/DNA Complex
Authors:Davies, D., Edwards, T., Gelinas, A., Jarvis, T., Clifton, M.C.
Deposit date:2013-11-05
Release date:2014-01-22
Modification date:2016-06-01
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of interleukin-6 in complex with a modified nucleic Acid ligand.
J.Biol.Chem., 289, 2014
4NI7
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CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN 6 IN COMPLEX WITH A MODIFIED NUCLEOTIDE APTAMER (SOMAMER SL1025)
Descriptor:Interleukin-6
Authors:Davies, D., Edwards, T., Gelinas, A., Jarvis, T., Clifton, M.C.
Deposit date:2013-11-05
Release date:2014-01-22
Modification date:2016-06-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of interleukin-6 in complex with a modified nucleic Acid ligand.
J.Biol.Chem., 289, 2014
4J4L
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MODULAR EVOLUTION AND DESIGN OF THE PROTEIN BINDING INTERFACE
Descriptor:Internalin B, Variable lymphocyte receptor B, Interleukin-6
Authors:Cheong, H.K., Kim, H.J.
Deposit date:2013-02-07
Release date:2014-02-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Modular evolution and design of the protein binding interface
To be Published
4CNI
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CRYSTAL STRUCTURE OF THE FAB PORTION OF OLOKIZUMAB IN COMPLEX WITH IL- 6
Descriptor:OLOKIZUMAB HEAVY CHAIN, FAB PORTION, OLOKIZUMAB LIGHT CHAIN, FAB PORTION, INTERLEUKIN-6
Authors:Shaw, S., Bourne, T., Meier, C., Carrington, B., Gelinas, R., Henry, A., Popplewell, A., Adams, R., Baker, T., Rapecki, S., Marshall, D., Neale, H., Lawson, A.
Deposit date:2014-01-22
Release date:2014-04-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery and Characterization of Olokizumab: A Humanized Antibody Targeting Interleukin-6 and Neutralizing Gp130-Signaling.
Mabs, 6, 2014
2L3Y
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SOLUTION STRUCTURE OF MOUSE IL-6
Descriptor:Interleukin-6
Authors:Veverka, V., Redpath, N.T., Carrington, B., Muskett, F.W., Taylor, R.J., Henry, A.J., Carr, M.D.
Deposit date:2010-09-25
Release date:2011-09-28
Modification date:2013-01-02
Method:SOLUTION NMR
Cite:Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention.
J.Biol.Chem., 287, 2012
2IL6
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HUMAN INTERLEUKIN-6, NMR, 32 STRUCTURES
Descriptor:INTERLEUKIN-6
Authors:Xu, G.Y., Yu, H.A., Hong, J., Stahl, M., Mcdonagh, T., Kay, L.E., Cumming, D.A.
Deposit date:1997-01-31
Release date:1998-02-04
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of recombinant human interleukin-6.
J.Mol.Biol., 268, 1997
1P9M
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CRYSTAL STRUCTURE OF THE HEXAMERIC HUMAN IL-6/IL-6 ALPHA RECEPTOR/GP130 COMPLEX
Descriptor:Interleukin-6 receptor beta chain, Interleukin-6, Interleukin-6 receptor alpha chain
Authors:Boulanger, M.J., Chow, D.C., Brevnova, E.E., Garcia, K.C.
Deposit date:2003-05-12
Release date:2003-07-01
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:Hexameric Structure and Assembly of the Interleukin-6/IL-6 alpha-Receptor/gp130 Complex
Science, 300, 2003
1IL6
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HUMAN INTERLEUKIN-6, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:INTERLEUKIN-6
Authors:Xu, G.Y., Yu, H.A., Hong, J., Stahl, M., Mcdonagh, T., Kay, L.E., Cumming, D.A.
Deposit date:1997-01-31
Release date:1998-02-04
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of recombinant human interleukin-6.
J.Mol.Biol., 268, 1997
1I1R
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CRYSTAL STRUCTURE OF A CYTOKINE/RECEPTOR COMPLEX
Descriptor:Interleukin-6 receptor beta chain/viral IL-6 complex
Authors:Chow, D., He, X., Snow, A.L., Rose-John, S., Garcia, K.C.
Deposit date:2001-02-02
Release date:2001-03-28
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of an extracellular gp130 cytokine receptor signaling complex.
Science, 291, 2001
1ALU
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HUMAN INTERLEUKIN-6
Descriptor:INTERLEUKIN-6, TARTARIC ACID
Authors:Somers, W.S., Stahl, M., Seehra, J.S.
Deposit date:1997-06-03
Release date:1998-06-03
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling.
EMBO J., 16, 1997
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