4O9H
Structure of Interleukin-6 in complex with a Camelid Fab fragment
Summary for 4O9H
Entry DOI | 10.2210/pdb4o9h/pdb |
Descriptor | Interleukin-6, Heavy Chain of the Camelid Fab fragment 61H7, Light Chain of the Camelid Fab fragment 61H7, ... (4 entities in total) |
Functional Keywords | il6: all alpha protein, fab: all beta protein, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P05231 |
Total number of polymer chains | 3 |
Total formula weight | 67171.20 |
Authors | Klarenbeek, A.,Blanchetot, C.,Schragel, G.,Sadi, A.S.,Ongenae, N.,Hemrika, W.,Wijdenes, J.,Spinelli, S.,Desmyter, A.,Cambillau, C.,Hultberg, A.,Kretz-rommel, A.,Dreier, T.,De haard, H.J.W.,Roovers, R.C. (deposition date: 2014-01-02, release date: 2015-04-15, Last modification date: 2015-04-29) |
Primary citation | Klarenbeek, A.,Blanchetot, C.,Schragel, G.,Sadi, A.S.,Ongenae, N.,Hemrika, W.,Wijdenes, J.,Spinelli, S.,Desmyter, A.,Cambillau, C.,Hultberg, A.,Kretz-Rommel, A.,Dreier, T.,De haard, H.J.W.,Roovers, R.C. Combining residues of naturally-occurring Camelid somatic affinity variants yields ultra-potent human therapeutic IL-6 antibodies To be Published, |
Experimental method | X-RAY DIFFRACTION (2.42 Å) |
Structure validation
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