8D82

Cryo-EM structure of human IL-6 signaling complex in detergent: model containing full extracellular domains

Summary for 8D82

• Entry DOI: 10.2210/pdb8d82/pdb
• EMDB information: 27244
• Descriptor: Soluble interleukin-6 receptor subunit alpha, Interleukin-6, Interleukin-6 receptor subunit beta, ... (5 entities in total)
• Functional Keywords: cytokine signaling, il-6, il-6r alpha, gp130, cytokine
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 281460.18

Authors

Zhou, Y.,Franklin, M.C. (deposition date: 2022-06-07, release date: 2023-03-29)

• Primary citation: Zhou, Y.,Stevis, P.E.,Cao, J.,Saotome, K.,Wu, J.,Glatman Zaretsky, A.,Haxhinasto, S.,Yancopoulos, G.D.,Murphy, A.J.,Sleeman, M.W.,Olson, W.C.,Franklin, M.C.; Structural insights into the assembly of gp130 family cytokine signaling complexes.; Sci Adv, 9:eade4395-eade4395, 2023; PubMed: 36930708; DOI: 10.1126/sciadv.ade4395

Experimental method

ELECTRON MICROSCOPY (3.22 Å)