1P9M
Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex
Summary for 1P9M
Entry DOI | 10.2210/pdb1p9m/pdb |
Descriptor | Interleukin-6 receptor beta chain, Interleukin-6, Interleukin-6 receptor alpha chain (3 entities in total) |
Functional Keywords | ig domain, four helix bundle, cytokine, interleukin-6, gp130, signaling protein-cytokine complex, signaling protein/cytokine |
Biological source | Homo sapiens (human) More |
Cellular location | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P40189 Secreted: P05231 Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P08887 |
Total number of polymer chains | 3 |
Total formula weight | 78253.48 |
Authors | Boulanger, M.J.,Chow, D.C.,Brevnova, E.E.,Garcia, K.C. (deposition date: 2003-05-12, release date: 2003-07-01, Last modification date: 2023-08-16) |
Primary citation | Boulanger, M.J.,Chow, D.C.,Brevnova, E.E.,Garcia, K.C. Hexameric Structure and Assembly of the Interleukin-6/IL-6 alpha-Receptor/gp130 Complex Science, 300:2101-2104, 2003 Cited by PubMed: 12829785DOI: 10.1126/science.1083901 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.65 Å) |
Structure validation
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