4ZS7
Structural mimicry of receptor interaction by antagonistic IL-6 antibodies
Summary for 4ZS7
Entry DOI | 10.2210/pdb4zs7/pdb |
Descriptor | Interleukin-6, Llama Fab fragment 68F2 heavy chain, Llama Fab fragment 68F2 light chain, ... (4 entities in total) |
Functional Keywords | interleukine 6 complex, fab fragment, dromedery, immune system |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted: P05231 |
Total number of polymer chains | 3 |
Total formula weight | 66442.40 |
Authors | Blanchetot, C.,De Jonge, N.,Desmyter, A.,Ongenae, N.,Hofman, E.,Klarenbeek, A.,Sadi, A.,Hultberg, A.,Kretz-Rommel, A.,Spinelli, S.,Loris, R.,Cambillau, C.,de Haard, H. (deposition date: 2015-05-13, release date: 2016-05-04, Last modification date: 2016-07-06) |
Primary citation | Blanchetot, C.,De Jonge, N.,Desmyter, A.,Ongenae, N.,Hofman, E.,Klarenbeek, A.,Sadi, A.,Hultberg, A.,Kretz-Rommel, A.,Spinelli, S.,Loris, R.,Cambillau, C.,de Haard, H. Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies. J.Biol.Chem., 291:13846-13854, 2016 Cited by PubMed: 27129274DOI: 10.1074/jbc.M115.695528 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.93 Å) |
Structure validation
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