1MIX
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CRYSTAL STRUCTURE OF A FERM DOMAIN OF TALIN
Descriptor:Talin
Authors:Garcia-Alvarez, B., de Pereda, J.M., Calderwood, D.A., Ulmer, T.S., Critchley, D., Campbell, I.D., Ginsberg, M.H., Liddington, R.C.
Deposit date:2002-08-23
Release date:2003-01-28
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural determinants of integrin recognition by talin
Mol.Cell, 11, 2003
1Y19
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STRUCTURAL BASIS FOR PHOSPHATIDYLINOSITOL PHOSPHATE KINASE TYPE I-GAMMA BINDING TO TALIN AT FOCAL ADHESIONS
Descriptor:Phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma, Talin 1
Authors:de Pereda, J.M., Wegener, K., Santelli, E., Bate, N., Ginsberg, M.H., Critchley, D.R., Campbell, I.D., Liddington, R.C.
Deposit date:2004-11-17
Release date:2005-01-04
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural bases for phosphatidylinositol phosphate kinase type I-gamma binding to talin at focal adhesions
J.Biol.Chem., 280, 2005
2AEH
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FOCAL ADHESION KINASE 1
Descriptor:Focal adhesion kinase 1 (E.C.2.7.1.112)
Authors:Ceccarelli, D.F., Song, H.K., Poy, F., Schaller, M.D., Eck, M.J.
Deposit date:2005-07-22
Release date:2005-10-18
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Crystal Structure of the FERM Domain of Focal Adhesion Kinase
J.Biol.Chem., 281, 2006
2AL6
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FERM DOMAIN OF FOCAL ADHESION KINASE
Descriptor:Focal adhesion kinase 1 (E.C.2.7.1.112)
Authors:Ceccarelli, D.F., Song, H.K., Poy, F., Schaller, M.D., Eck, M.J.
Deposit date:2005-08-04
Release date:2005-10-18
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal Structure of the FERM Domain of Focal Adhesion Kinase
J.Biol.Chem., 281, 2006
2G35
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NMR STRUCTURE OF TALIN-PTB IN COMPLEX WITH PIPKI
Descriptor:Talin-1
Authors:Kong, X., Wang, X., Misra, S., Qin, J.
Deposit date:2006-02-17
Release date:2006-05-02
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Structural Basis for the Phosphorylation-regulated Focal Adhesion Targeting of Type Igamma Phosphatidylinositol Phosphate Kinase (PIPKIgamma) by Talin.
J.Mol.Biol., 359, 2006
2H7D
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SOLUTION STRUCTURE OF THE TALIN F3 DOMAIN IN COMPLEX WITH A CHIMERIC BETA3 INTEGRIN-PIP KINASE PEPTIDE
Descriptor:Talin-1, Chimera of 24-mer peptide from Integrin beta-3 and 10-mer peptide from Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma
Authors:Wegener, K.L.
Deposit date:2006-06-02
Release date:2007-01-30
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Structural basis of integrin activation by talin
CELL(CAMBRIDGE,MASS.), 128, 2007
2H7E
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SOLUTION STRUCTURE OF THE TALIN F3 DOMAIN IN COMPLEX WITH A CHIMERIC BETA3 INTEGRIN-PIP KINASE PEPTIDE- MINIMIZED AVERAGE STRUCTURE
Descriptor:Talin-1, Chimera of 24-mer peptide from Integrin beta-3 and 10-mer peptide from Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma
Authors:Wegener, K.L.
Deposit date:2006-06-02
Release date:2007-01-30
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Structural basis of integrin activation by talin
CELL(CAMBRIDGE,MASS.), 128, 2007
2HRJ
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NMR SOLUTION STRUCTURE OF THE F2 SUBDOMAIN OF TALIN
Descriptor:Talin-1
Authors:Liu, G., Arroyo, M.M., Zheng, J.
Deposit date:2006-07-20
Release date:2008-04-29
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Structural characterization of the talin F2 FERM subdomain with Coenzyme A and PI(4,5)P2
To be Published
2K00
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SOLUTION STRUCTURE OF THE TALIN F3 IN COMPLEX WITH LAYILIN CYTODOMAIN
Descriptor:Talin-1, Layilin
Authors:Wegener, K.L., Barsukov, I.L.
Deposit date:2008-01-23
Release date:2008-09-09
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain
J.Mol.Biol., 382, 2008
2KGX
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HADDOCK STRUCTURE OF THE TALIN F3 DOMAIN IN COMPLEX WITH TALIN 1655-1822
Descriptor:Talin-1, MKIAA1027 protein
Authors:Goult, B.T., Gingras, A.R., Bate, N., Critchley, D.R., Barsukov, I.L.
Deposit date:2009-03-23
Release date:2009-03-31
Modification date:2009-07-07
Method:SOLUTION NMR
Cite:The structure of an interdomain complex that regulates talin activity.
J.Biol.Chem., 284, 2009
2LKO
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STRUCTURAL BASIS OF PHOSPHOINOSITIDE BINDING TO KINDLIN-2 PLECKSTRIN HOMOLOGY DOMAIN IN REGULATING INTEGRIN ACTIVATION
Descriptor:Fermitin family homolog 2
Authors:Liu, J., Fukuda, K., Xu, Z.
Deposit date:2011-10-17
Release date:2011-10-26
Modification date:2011-12-28
Method:SOLUTION NMR
Cite:Structural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activation.
J.Biol.Chem., 286, 2011
2MSU
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NMR STRUCTURE OF KINDLIN-2 F2 339-358
Descriptor:Fermitin family homolog 2
Authors:Fukuda, K., Bledzka, K., Yang, J., Perera, H.D.
Deposit date:2014-08-05
Release date:2014-08-27
Modification date:2014-10-29
Method:SOLUTION NMR
Cite:Molecular Basis of Kindlin-2 Binding to Integrin-linked Kinase Pseudokinase for Regulating Cell Adhesion.
J.Biol.Chem., 289, 2014
2MWN
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TALIN-F3 / RIAM N-TERMINAL PEPTIDE COMPLEX
Descriptor:Amyloid beta A4 precursor protein-binding family B member 1-interacting protein, Talin-1
Authors:Yang, J., Zhu, L., Zhang, H., Hirbawi, J., Fukuda, K., Dwivedi, P., Liu, J., Byzova, T., Plow, E.F., Wu, J., Qin, J.
Deposit date:2014-11-13
Release date:2014-12-17
Modification date:2015-01-14
Method:SOLUTION NMR
Cite:Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion.
Nat Commun, 5, 2014
2RQ1
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SOLUTION STRUCTURE OF THE 4.1R FERM ALPHA LOBE DOMAIN
Descriptor:Protein 4.1
Authors:Kusunoki, H., Kohno, T.
Deposit date:2009-01-09
Release date:2009-04-14
Modification date:2009-05-19
Method:SOLUTION NMR
Cite:Solution structure and glycophorin C binding studies of the protein 4.1R FERM alpha-lobe domain
Proteins, 76, 2009
2YS3
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SOLUTION STRUCTURE OF THE PH DOMAIN OF KINDLIN-3 FROM HUMAN
Descriptor:Unc-112-related protein 2
Authors:Li, H., Sato, M., Koshiba, S., Watanabe, S., Harada, T., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-04-03
Release date:2007-10-09
Modification date:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of the PH domain of Kindlin-3 from human
To be Published
3U7D
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CRYSTAL STRUCTURE OF THE KRIT1/CCM1 FERM DOMAIN IN COMPLEX WITH THE HEART OF GLASS (HEG1) CYTOPLASMIC TAIL
Descriptor:Krev interaction trapped protein 1, Protein HEG homolog 1
Authors:Gingras, A.R., Liu, J.J., Ginsberg, M.H., Assembly, Dynamics and Evolution of Cell-Cell and Cell-Matrix Adhesions (CELLMAT)
Deposit date:2011-10-13
Release date:2012-09-12
Modification date:2013-02-27
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural basis of the junctional anchorage of the cerebral cavernous malformations complex.
J.Cell Biol., 199, 2012
3ZDT
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CRYSTAL STRUCTURE OF BASIC PATCH MUTANT FAK FERM DOMAIN FAK31- 405 K216A, K218A, R221A, K222A
Descriptor:FOCAL ADHESION KINASE 1 (E.C.2.7.10.2)
Authors:Goni, G.M., Epifano, C., Boskovic, J., Camacho-Artacho, M., Zhou, J., Martin, M.T., Eck, M.J., Kremer, L., Graeter, F., Gervasio, F.L., Perez-Moreno, M., Lietha, D.
Deposit date:2012-11-30
Release date:2012-12-12
Modification date:2014-08-20
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Phosphatidylinositol 4,5-Bisphosphate Triggers Activation of Focal Adhesion Kinase by Inducing Clustering and Conformational Changes.
Proc.Natl.Acad.Sci.USA, 111, 2014
4CYE
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CRYSTAL STRUCTURE OF AVIAN FAK FERM DOMAIN FAK31-405 AT 3.2A
Descriptor:FOCAL ADHESION KINASE 1 (E.C.2.7.10.2)
Authors:Goni, G.M., Epifano, C., Boskovic, J., Camacho-Artacho, M., Zhou, J., Martin, M.T., Eck, M.J., Kremer, L., Graeter, F., Gervasio, F.L., Perez-Moreno, M., Lietha, D.
Deposit date:2014-04-10
Release date:2014-04-23
Modification date:2014-08-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Phosphatidylinositol 4,5-Bisphosphate Triggers Activation of Focal Adhesion Kinase by Inducing Clustering and Conformational Changes.
Proc.Natl.Acad.Sci.USA, 111, 2014
4EKU
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CRYSTAL STRUCTURE OF FERM DOMAIN OF PROLINE-RICH TYROSINE KINASE 2
Descriptor:Protein-tyrosine kinase 2-beta (E.C.2.7.10.2)
Authors:Savarimuthu, B., Li, R., Wang, Y.
Deposit date:2012-04-09
Release date:2012-04-25
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Crystal Structure of the Ferm Domain of Proline-rich Tyrosine Kinase 2
To be Published
4F7G
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CRYSTAL STRUCTURE OF TALIN AUTOINHIBITION COMPLEX
Descriptor:Talin-1
Authors:Song, X., Qin, J., Ye, S., Zhang, R.
Deposit date:2012-05-16
Release date:2012-07-04
Modification date:2012-11-21
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion.
Cell Res., 22, 2012
4F7H
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THE CRYSTAL STRUCTURE OF KINDLIN-2 PLECKSTRIN HOMOLOGY DOMAIN IN FREE FORM
Descriptor:Fermitin family homolog 2
Authors:Liu, Y., Zhu, Y., Qin, J., Ye, S., Zhang, R.
Deposit date:2012-05-16
Release date:2012-06-13
Modification date:2012-07-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of kindlin-2 PH domain reveals a conformational transition for its membrane anchoring and regulation of integrin activation.
Protein Cell, 3, 2012
4NY0
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CRYSTAL STRUCTURE OF FERM DOMAIN OF HUMAN FOCAL ADHESION KINASE
Descriptor:Focal adhesion kinase 1 (E.C.2.7.10.2)
Authors:Walkiewicz, K., Arold, S.T.
Deposit date:2013-12-10
Release date:2014-03-12
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:FAK dimerization controls its kinase-dependent functions at focal adhesions.
Embo J., 33, 2014
1E5W
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STRUCTURE OF ISOLATED FERM DOMAIN AND FIRST LONG HELIX OF MOESIN
Descriptor:MOESIN
Authors:Edwards, S.D., Keep, N.H.
Deposit date:2000-08-03
Release date:2001-06-27
Modification date:2015-02-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The 2.7 A Crystal Structure of the Activated Ferm Domain of Moesin: An Analysis of Structural Changes on Activation
Biochemistry, 40, 2001
1EF1
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CRYSTAL STRUCTURE OF THE MOESIN FERM DOMAIN/TAIL DOMAIN COMPLEX
Descriptor:CRYSTAL STRUCTURE OF THE MOESIN FERM DOMAIN/TAIL DOMAIN COMPLEX
Authors:Pearson, M.A., Reczek, D., Bretscher, A., Karplus, P.A.
Deposit date:2000-02-04
Release date:2000-05-10
Modification date:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain.
Cell(Cambridge,Mass.), 101, 2000
1GC6
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CRYSTAL STRUCTURE OF THE RADIXIN FERM DOMAIN COMPLEXED WITH INOSITOL-(1,4,5)-TRIPHOSPHATE
Descriptor:THE RADIXIN FERM DOMAIN COMPLEXED WITH INOSITOL-(1,4,5)-TRIPHOSPHATE
Authors:Hamada, K., Shimizu, T., Matsui, T., Tsukita, S., Tsukita, S., Hakoshima, T.
Deposit date:2000-07-21
Release date:2000-09-20
Modification date:2009-02-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain.
EMBO J., 19, 2000
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