8GVL

PTPN21 FERM

Summary for 8GVL

• Entry DOI: 10.2210/pdb8gvl/pdb
• Descriptor: Tyrosine-protein phosphatase non-receptor type 21, (4S)-2-METHYL-2,4-PENTANEDIOL (3 entities in total)
• Functional Keywords: ptpn21, phosphotase, ferm, protein binding
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 70567.94

Authors

Chen, L.,Zheng, Y.Y.,Zhou, C. (deposition date: 2022-09-15, release date: 2023-09-20, Last modification date: 2024-04-17)

• Primary citation: Chen, L.,Qian, Z.,Zheng, Y.,Zhang, J.,Sun, J.,Zhou, C.,Xiao, H.; Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity.; Sci Adv, 10:eadi7404-eadi7404, 2024; PubMed: 38416831; DOI: 10.1126/sciadv.adi7404

Experimental method

X-RAY DIFFRACTION (2.1 Å)