7LWH

Human neurofibromin 2/merlin residues 1-339 in complex with LATS1

Summary for 7LWH

• Entry DOI: 10.2210/pdb7lwh/pdb
• Descriptor: Merlin, Serine/threonine-protein kinase LATS1, IMIDAZOLE, ... (5 entities in total)
• Functional Keywords: actin, cancer, cell adhesion, cell junction, cell migration, cell signaling, inositol phospholipid, neurofibromatosis type 2, plasma membrane
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 43159.94

Authors

Primi, M.C.,Rangarajan, E.S.,Izard, T. (deposition date: 2021-03-01, release date: 2021-08-11, Last modification date: 2023-10-18)

• Primary citation: Primi, M.C.,Rangarajan, E.S.,Patil, D.N.,Izard, T.; Conformational flexibility determines the Nf2/merlin tumor suppressor functions.; Matrix Biol Plus, 12:100074-100074, 2021; PubMed: 34337379; DOI: 10.1016/j.mbplus.2021.100074

Experimental method

X-RAY DIFFRACTION (1.606 Å)